Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1Slalom mutation
(2 available);
any
Jag1 mutation
(76 available)
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mortality/aging
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• survival to about E12.5
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embryo
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• reduced large vasculature in yolk sac
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• neural tube defects in about 30% of embryos
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nervous system
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• neural tube defects in about 30% of embryos
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cardiovascular system
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• reduced large vasculature in yolk sac
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Allelic Composition |
Jag1Slalom/Jag1+
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Genetic Background |
involves: BALB/c * C3H |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1Slalom mutation
(2 available);
any
Jag1 mutation
(76 available)
|
|
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behavior/neurological
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• subtle headweaving/shaking behavior
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• described as poor negative geotaxis
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hearing/vestibular/ear
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• supernumary or atypical outer hair cells sometimes found in inner hair cell rows
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• reduced numbers of outer hair cells
• some regions lacking entire rows while isolated hair cells missing in other regions
• decreased outer hair cell counts in both basal and apical turns
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• significantly increased inner hair cell counts in base of cochlea but not apical regions
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• either posterior or anterior semicircular canal truncated
• sometimes both anterior and posterior semicircular canals absent
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nervous system
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• reduced numbers of outer hair cells
• some regions lacking entire rows while isolated hair cells missing in other regions
• decreased outer hair cell counts in both basal and apical turns
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• significantly increased inner hair cell counts in base of cochlea but not apical regions
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mortality/aging
embryo
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• absence of blood vessels in the yolk sac
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• embryos are either necrotic or hemorrhagic
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cardiovascular system
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• absence of blood vessels in the yolk sac
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• embryos are either necrotic or hemorrhagic
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cellular
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• embryos are either necrotic or hemorrhagic
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