About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Serpinb2tm1Dgi
targeted mutation 1, David Ginsburg
MGI:1931532
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Serpinb2tm1Dgi/Serpinb2tm1Dgi involves: 129S2/SvPas * C57BL/6J * DBA/2J MGI:3037850
cx2
 		Serpinb2tm1Dgi/Serpinb2tm1Dgi
Serpine1tm1Mlg/Serpine1tm1Mlg 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * DBA/2 MGI:4837628
cx3
 		Dusp5tm1.1Skey/Dusp5tm1.1Skey
Serpinb2tm1Dgi/Serpinb2tm1Dgi 		involves: 129S1/Sv * C57BL/6 * C57BL/6NTac MGI:5906772


Genotype
MGI:3037850
hm1
Allelic
Composition		 Serpinb2tm1Dgi/Serpinb2tm1Dgi
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinb2tm1Dgi mutation (1 available); any Serpinb2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:52283 )
• decreased platelet count of marginal significance
abnormal leukocyte cell number ( J:52283 )
• a marginally significant decrease in leukocyte count involving lymphocytes, neutrophils, and monocytes

immune system
immune system phenotype ( J:52283 )
N
• mice exhibit normal response to bacterial infectious challenge or endotoxin infusion
abnormal leukocyte cell number ( J:52283 )
• a marginally significant decrease in leukocyte count involving lymphocytes, neutrophils, and monocytes

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:52283 )
N
• mice exhibit normal wound healing




Genotype
MGI:4837628
cx2
Allelic
Composition		 Serpinb2tm1Dgi/Serpinb2tm1Dgi
Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinb2tm1Dgi mutation (1 available); any Serpinb2 mutation (32 available)
Serpine1tm1Mlg mutation (4 available); any Serpine1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:52283 )
N
• mice exhibit normal wound healing




Genotype
MGI:5906772
cx3
Allelic
Composition		 Dusp5tm1.1Skey/Dusp5tm1.1Skey
Serpinb2tm1Dgi/Serpinb2tm1Dgi
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dusp5tm1.1Skey mutation (0 available); any Dusp5 mutation (16 available)
Serpinb2tm1Dgi mutation (1 available); any Serpinb2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:216939 )
N
• mice exhibit normal susceptibility to DMBA/TPA-induced skin papilloma




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory