Phenotypes associated with this allele

• Allele Symbol: Vegfa^tm1Dco
• Allele Name: targeted mutation 1, Desire Collen
• Allele ID: MGI:1931046
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vegfa^tm1Dco/Vegfa^tm1Dco	involves: 129	MGI:3849560
ht2	Vegfa^tm1Dco/Vegfa^+	involves: 129	MGI:3849561

Genotype
MGI:3849560

hm1

• Allelic Composition: Vegfa^tm1Dco/Vegfa^tm1Dco
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:32219 )

• no viable mice are obtained at birth

cardiovascular system

abnormal vascular development ( J:32219 )

• at E9.5, vascular structures are enlarged in the anterior part of the embryo

abnormal dorsal aorta morphology ( J:32219 )

• at E8.5, the dorsal aorta is absent in the anterior part of the embryo

abnormal vascular endothelial cell differentiation ( J:32219 )

• endothelial cell development is delayed compared to in wild-type mice

cellular

abnormal vascular endothelial cell differentiation ( J:32219 )

• endothelial cell development is delayed compared to in wild-type mice

Genotype
MGI:3849561

ht2

• Allelic Composition: Vegfa^tm1Dco/Vegfa⁺
• Genetic Background: involves: 129

cardiovascular system

abnormal dorsal aorta morphology ( J:32219 )

• the dorsal aorta has a smaller lumen and fewer endothelial cells than in wild-type mice

• at E9.5, the anterior part of the dorsal aorta is poorly developed

decreased angiogenesis ( J:32219 )

• the density of sprouting intersomitic and head mesenchyme vessels is decreased compared to in wild-type mice

abnormal vitelline vasculature morphology ( J:32219 )

• at E9.5, yolk sacs display an irregular plexus of small vessels with no larger collecting vessels unlike in wild-type mice

• however, endothelial cell density and proliferation rates are normal

embryo

abnormal vitelline vasculature morphology ( J:32219 )

• at E9.5, yolk sacs display an irregular plexus of small vessels with no larger collecting vessels unlike in wild-type mice

• however, endothelial cell density and proliferation rates are normal