Phenotypes associated with this allele

• Allele Symbol: Vegfa^tm1Gne
• Allele Name: targeted mutation 1, Genentech
• Allele ID: MGI:1931041
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Vegfa^tm1Gne/Vegfa^+	involves: 129S2/SvPas * C57BL/6J	MGI:2174800

Genotype
MGI:2174800

ht1

• Allelic Composition: Vegfa^tm1Gne/Vegfa⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:32218 )

• heterozygotes die between E11 and E12

embryo

abnormal placenta vasculature ( J:32218 )

• at E10.5, mutant placentas exhibit a condensed vasculature with a degenerating endothelium lining the fetal capillaries

abnormal vitelline vasculature morphology ( J:32218 )

• at E9.5-E11.5, several heterozygotes display an apparent absence of blood supply in the yolk sac

abnormal vitelline vein morphology ( J:32218 )

• at E9.5-E11.5, vitelline veins fail to fuse with the yolk sac

increased embryonic tissue cell apoptosis ( J:32218 )

• at E11.5, heterozygus mutant embryos exhibit significant apoptosis, consistent with a vascular deficit

abnormal pharyngeal arch morphology ( J:32218 )

• at E9.5-E12.5, heterozygotes display poorly developed and unsegmented branchial arches in the cranial region

abnormal forelimb bud morphology ( J:32218 )

• at E9.5-E11.5, the forelimb buds of heterozygotes are abnormally located at the earlier caudal position and appear unsegmented

abnormal visceral yolk sac blood island morphology ( J:32218 )

• at E9.5-E11.5, heterozygotes show significantly less nucleated red blood cells in the blood islands

cardiovascular system

abnormal blood vessel morphology ( J:32218 )

• at E10.5, heterozygotes display abnormal vascular patterns in the placenta and forebrain

abnormal dorsal aorta morphology ( J:32218 )

• at E9.5-E11.5, heterozygotes exhibit a rudimentary dorsal aorta

abnormal placenta vasculature ( J:32218 )

• at E10.5, mutant placentas exhibit a condensed vasculature with a degenerating endothelium lining the fetal capillaries

abnormal vitelline vasculature morphology ( J:32218 )

• at E9.5-E11.5, several heterozygotes display an apparent absence of blood supply in the yolk sac

abnormal vitelline vein morphology ( J:32218 )

• at E9.5-E11.5, vitelline veins fail to fuse with the yolk sac

delayed heart development ( J:32218 )

• at E9.5-E11.5, the common atrium and primitive ventricle are developmentally delayed

• at E10.5, heterozygotes show lack of myoblast differentiation in the cardiac region

thin ventricular wall ( J:32218 )

• at E9.5-E11.5, heterozygotes show a significantly thinned ventricular wall

nervous system

increased embryonic neuroepithelium apoptosis ( J:32218 )

• at E10.5, heterozygotes exhibit increased apoptosis and disorganization of neuroepithelial cells

abnormal forebrain development ( J:32218 )

• at E9.5-E11.5, heterozygotes display an underdeveloped forebrain region with vascular elements present in the mesenchyme but not in the neuroepithelium

limbs/digits/tail

abnormal forelimb bud morphology ( J:32218 )

• at E9.5-E11.5, the forelimb buds of heterozygotes are abnormally located at the earlier caudal position and appear unsegmented

craniofacial

abnormal pharyngeal arch morphology ( J:32218 )

• at E9.5-E12.5, heterozygotes display poorly developed and unsegmented branchial arches in the cranial region

cellular

increased embryonic tissue cell apoptosis ( J:32218 )

• at E11.5, heterozygus mutant embryos exhibit significant apoptosis, consistent with a vascular deficit

increased embryonic neuroepithelium apoptosis ( J:32218 )

• at E10.5, heterozygotes exhibit increased apoptosis and disorganization of neuroepithelial cells