Phenotypes associated with this allele
Allelic Composition |
H19tm1Tilg/H19+
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Genetic Background |
involves: 129S/SvEv |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19tm1Tilg mutation
(1 available);
any
H19 mutation
(12 available)
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embryo
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• placentas are 54% heavier at E18.5 than in wild-type when the mutated allele is inherited maternally
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growth/size/body
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• heterozygotes inheriting the mutant allele from the mother exhibit an increase in body mass (28% difference from wild-type)
(J:25091)
• heavier than controls at E18.5 when the mutated allele is inherited maternally
(J:75054)
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cellular
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• defects are seen in heterozygotes that receive the mutant allele from the mother while those that receive the mutant allele from the father are normal
(J:25091)
• when maternally inherited, the maternal H19 gene is repressed and the normally imprinted Igf2 and Ins-2 genes are expressed
(J:25091)
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Allelic Composition |
H19tm1.1Sriv/H19tm1Tilg
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Genetic Background |
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * FVB/N |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19tm1.1Sriv mutation
(0 available);
any
H19 mutation
(12 available)
H19tm1Tilg mutation
(1 available);
any
H19 mutation
(12 available)
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cellular
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• methylation is altered such that maternal Igf2 is aberrantly expressed
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Allelic Composition |
H19tm1Tilg/H19+ Sdhdtm1Jpb/Sdhd+
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Genetic Background |
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19tm1Tilg mutation
(1 available);
any
H19 mutation
(12 available)
Sdhdtm1Jpb mutation
(0 available);
any
Sdhd mutation
(16 available)
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neoplasm
N |
• no paragangliomas nor pheochromocytomas are detected in mice at up to 29 months of age in contrast to expectations from human disease data
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nervous system
N |
• no significant changes in carotid body or the adrenal medulla are seen
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growth/size/body
N |
• indistinguishable in size from wild-type in birth weights and postnatal growth rates
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3tm1Arge mutation
(0 available);
any
Gpc3 mutation
(17 available)
H19tm1Tilg mutation
(1 available);
any
H19 mutation
(12 available)
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mortality/aging
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• about 70% of double mutants that inherit the H19 allele maternally are stillborn
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• some additional mutants (that inherit the H19 allele maternally) that survive the perinatal period die before weaning
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cellular
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• defects are seen in double mutants that receive the H19 mutant allele from the mother
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3tm1Arge mutation
(0 available);
any
Gpc3 mutation
(17 available)
H19tm1Tilg mutation
(1 available);
any
H19 mutation
(12 available)
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mortality/aging
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• about 70% of double mutant males that inherit the H19 allele maternally are stillborn
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• some additional mutants (that inherit the H19 allele maternally) that survive the perinatal period die before weaning
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embryo
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• placentas are 94% heavier at E18.5 than in wild-type in double mutants that inherit the H19 allele maternally
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growth/size/body
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• double mutants that inherit the H19 allele maternally are heavier than wildtype at E18.5, but similar in weight as either single mutant
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• seen in 13 of 16 double mutants that inherit the H19 allele maternally
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skeleton
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• 3 of 6 double mutants that inherit the H19 allele maternally exhibit asymmetrical and staggered attachment of the ribs to the sternum
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• ossification of the sternum throughout its length
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• in 3 of 6 mutants double mutants that inherit the H19 allele maternally, the cartilage of the xiphisternum is bifurcated
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• one severely affected double mutant with the fusion of the first two ribs also has an extra (14th) pair of rudimentary ribs associated with the first pair of lumbar vertebrae
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• one severely affected double mutant shows unilateral fusion of the first two ribs in the middle portion
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cellular
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• defects are seen in double mutants that receive the H19 mutant allele from the mother
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Enl mutation
(0 available);
any
Dnmt1 mutation
(108 available)
H19tm1Tilg mutation
(1 available);
any
H19 mutation
(12 available)
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cellular
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• Ifg2 expression is normal indicating that imprinting is normal at this locus
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19tm1Tilg mutation
(1 available);
any
H19 mutation
(12 available)
Tg(CRP-TAg)60-3Urt mutation
(0 available)
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liver/biliary system
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• by 6 months mice with paternal inheritance of H19tm1Lda develop liver tumors unlike in wild-type mice
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mortality/aging
N |
• mice with paternal inheritance of H19tm1Lda live longer than those expressing only Tg(CRP-TAg)60-3Urt
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neoplasm
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• by 6 months mice with paternal inheritance of H19tm1Lda develop liver tumors unlike in wild-type mice
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• when H19tm1Lda is inherited paternally, mice display a more than 3 week delay in spontaneous tumorigenesis and subsequent mortality associated with Tg(CRP-TAg)60-3Urt expression
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