All Phenotypes Brca1<tm1Arge> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brca1^tm1Arge/Brca1^tm1Arge	involves: 129S/SvEv * C57BL/6	MGI:2174674
ht2	Brca1^tm1Arge/Brca1⁺	involves: 129S/SvEv * C57BL/6	MGI:2174675
cn3	Brca1^tm1Arge/Brca1^tm1Thl Wap^tm1(cre)Arge/0	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3805032
cn4	Brca1^tm1Arge/Brca1^tm1Arge Tg(Hsp70-1-cre)1Arge/0	involves: 129S/SvEv * C57BL/6J * CBA	MGI:3805031
cx5	Bard1^tm1Thl/Bard1^tm1Thl Brca1^tm1Arge/Brca1^tm1Arge	involves: 129S/SvEv * 129S1/Sv	MGI:2675414
cx6	Brca1^tm1Arge/Brca1^tm1Arge Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	MGI:2177217
cx7	Brca1^tm1Arge/Brca1^tm1Arge Brca2^tm1Arge/Brca2^tm1Arge	involves: 129S/SvEv * C57BL/6	MGI:2177216

Allelic Composition	Brca1^tm1Arge/Brca1^tm1Arge
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Arge mutation (0 available); any Brca1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:40594 )

• E5.5 -E8.5

embryo

embryonic growth retardation ( J:40594 )

abnormal embryonic tissue morphology ( J:40594 )

• some decidua contained only giant cells and extraembryonic membranes, and others also contained some embryonic remnants

abnormal egg cylinder morphology ( J:40594 )

• at E5.5, embryonic tissue, when present, appears as small and short egg cylinders compared to controls; no clear division between embryonic and extraembryonic tissue is apparent

• at E6.5, embryos, when present, are half the size of controls and were two-layered cylinders

• at E6.5, mutants lack amniotic folds and the primary giant cells are prominent and large

• at E7.5, embryos are small egg cylinders without amniotic folds and embryonic mesoderm is not visible; some extraembryonic tissue development appears normal

• at E8.5, remaining embryos are variable in shape and achieved developmental stage; some consist of only extraembryonic tissue, some have rudimentary embryonic epithelium with no mesoderm, while others appear to have developed further to the heart beat stage, although the embryo is severely reduced in size

• at E9.5, remaining embryos are variable in shape and achieved developmental stage

absent mesoderm ( J:40594 )

absent amniotic folds ( J:40594 )

growth/size/body

embryonic growth retardation ( J:40594 )

reproductive system

empty decidua capsularis ( J:40594 )

• many empty decidua found

Allelic Composition	Brca1^tm1Arge/Brca1⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Arge mutation (0 available); any Brca1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:40594 )

• up to 15 months of age; in particular, no tumors are detected

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Brca1^tm1Arge/Brca1^tm1Arge Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129S/SvEv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Arge mutation (0 available); any Brca1 mutation (113 available)
Tg(Hsp70-1-cre)1Arge mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:134977 )

• lethality occurs early in embryonic development

Allelic Composition	Bard1^tm1Thl/Bard1^tm1Thl Brca1^tm1Arge/Brca1^tm1Arge
Genetic Background	involves: 129S/SvEv * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm1Thl mutation (0 available); any Bard1 mutation (54 available)
Brca1^tm1Arge mutation (0 available); any Brca1 mutation (113 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:84329 )

• authors state that this phenotype is identical to homozygous Bard1^tm1Thl

embryo

abnormal developmental patterning ( J:84329 )

• authors state that this phenotype is identical to homozygous Bard1^tm1Thl

abnormal embryonic tissue morphology ( J:84329 )

• authors state that this phenotype is identical to homozygous Bard1^tm1Thl

Allelic Composition	Brca1^tm1Arge/Brca1^tm1Arge Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Arge mutation (0 available); any Brca1 mutation (113 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:40594 )

growth/size/body

embryonic growth retardation ( J:40594 )

• although double homozygous embryos are overtly retarded and abnormal compared to controls, Trp53 deficiency appears to partially rescue the Brca1 homozygous phenotype in that the embryos develop to a more advanced stage

embryo

embryonic growth retardation ( J:40594 )

Allelic Composition	Brca1^tm1Arge/Brca1^tm1Arge Brca2^tm1Arge/Brca2^tm1Arge
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Arge mutation (0 available); any Brca1 mutation (113 available)
Brca2^tm1Arge mutation (0 available); any Brca2 mutation (132 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:40594 )

• embryonic lethal prior to E9.5

embryo

abnormal embryonic tissue morphology ( J:40594 )

• of two double homozygotes recovered at E9.5, one consisted of an allantois with a severely reduced embryonic region and the other consisted of a yolk sac and giant cells only

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