Phenotypes associated with this allele

• Allele Symbol: Tcf15^tm1Eno
• Allele Name: targeted mutation 1, Eric N Olson
• Allele ID: MGI:1929775
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf15^tm1Eno/Tcf15^tm1Eno	involves: 129S7/SvEvBrd * C57BL/6	MGI:2174755

Genotype
MGI:2174755

hm1

• Allelic Composition: Tcf15^tm1Eno/Tcf15^tm1Eno
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:37117 )

• homozygotes die within one hour after birth

embryo

caudal body truncation ( J:37117 )

• posterior truncation is first evident at E13

• newborn homozygotes show absence of skeletal or cartilaginous elements posterior to the pelvis

short rostral-caudal axis ( J:37117 )

• newborn homozygotes exhibit severe truncation of the anterior-posterior axis

abnormal paraxial mesoderm morphology ( J:37117 )

• cells from the mutant paraxial mesoderm fail to form epithelia, resulting in disrupted somite formation

impaired somite development ( J:37117 )

• homozygotes exhibit deficient somite epithelialization

skeleton

abnormal axial skeleton morphology ( J:37117 )

abnormal craniofacial bone morphology ( J:37117 )

abnormal basioccipital bone morphology ( J:37117 )

• mutant basioccipital and exoccipital bones are fused to each other and to an abnormal skeletal structure that is probably a remnant of the atlas

abnormal exoccipital bone morphology ( J:37117 )

• mutant basioccipital and exoccipital bones are fused to each other and to an abnormal skeletal structure that is probably a remnant of the atlas

abnormal supraoccipital bone morphology ( J:37117 )

abnormal sternocostal joint morphology ( J:37117 )

• mutant sterna lack intersternebral cartilage which attaches ribs to the sternum

abnormal sternum ossification ( J:37117 )

• newborn homozygotes display overossified sterna that lack intersternebral cartilage

abnormal costovertebral joint morphology ( J:37117 )

• mutant ribs are detached from the vertebral column

abnormal rib morphology ( J:37117 )

• newborn homozygotes display underossified, malformed ribs, despite obvious segmental periodicity

decreased rib number ( J:37117 )

• newborn homozygotes lack several posterior ribs

rib bifurcation ( J:37117 )

rib fusion ( J:37117 )

abnormal spine curvature ( J:37117 )

• newborn homozygotes exhibit a vertebral column of abnormal cervical flexure

abnormal vertebrae morphology ( J:37117 )

• newborn homozygotes have cervical, thoracic and lumbar vertebrae but display an unsegmented cartilaginous mass that extends from the sacral region into the pelvis

• mutants exhibit 20-25 vertebral structures with dual ossification centers in the ventromedial region, random fusions in the lateral region, and malformations

fusion of atlas and occipital bones ( J:37117 )

• mutant basioccipital and exoccipital bones are fused to each other and to an abnormal skeletal structure that is probably a remnant of the atlas

absent sclerotome ( J:37117 )

• at E11.5, homozygotes lack a clearly identifiable sclerotome in transverse sections of the caudal tail region

craniofacial

abnormal craniofacial bone morphology ( J:37117 )

abnormal basioccipital bone morphology ( J:37117 )

• mutant basioccipital and exoccipital bones are fused to each other and to an abnormal skeletal structure that is probably a remnant of the atlas

abnormal exoccipital bone morphology ( J:37117 )

• mutant basioccipital and exoccipital bones are fused to each other and to an abnormal skeletal structure that is probably a remnant of the atlas

abnormal supraoccipital bone morphology ( J:37117 )

fusion of atlas and occipital bones ( J:37117 )

• mutant basioccipital and exoccipital bones are fused to each other and to an abnormal skeletal structure that is probably a remnant of the atlas

lowered ear position ( J:37117 )

muscle

absent myotome ( J:37117 )

• at E11.5, homozygotes lack a clearly identifiable myotome in transverse sections of the caudal tail region

abnormal skeletal muscle morphology ( J:37117 )

• newborn homozygotes show several defects in axial musculature and muscles of the limb and body wall

abnormal intercostal muscle morphology ( J:37117 )

• mutant intercostal muscles are hypertrophic and abnormally patterned

skeletal muscle hypertrophy ( J:37117 )

• mutant limb muscles are hypertrophic and abnormally patterned

limbs/digits/tail

short tail ( J:37117 )

curly tail ( J:37117 )

behavior/neurological

aphagia ( J:37117 )

• newborn homozygotes fail to feed

abnormal limb posture ( J:37117 )

• newborn homozygotes display abnormal limb posture

hearing/vestibular/ear

lowered ear position ( J:37117 )

respiratory system

respiratory distress ( J:37117 )

growth/size/body

lowered ear position ( J:37117 )

abnormal abdominal wall morphology ( J:37117 )

• newborn homozygotes lack the transverse abdominal muscle of the abdominal wall

integument

loose skin ( J:37117 )

absent dermatome ( J:37117 )

• at E11.5, homozygotes lack a clearly identifiable dermatome in transverse sections of the caudal tail region