Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch4tm1Grid mutation
(2 available);
any
Notch4 mutation
(87 available)
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normal phenotype
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• homozygotes display normal embryonic growth and adults are viable, fertile and indistinguishable from control littermates
• virgin, pregnant, and lactating females show no apparent defects in mammary gland development
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch4tm1Grid mutation
(2 available);
any
Notch4 mutation
(87 available)
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cardiovascular system
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• P5 retinas show a 17.4% reduction in the area covered by the vascular plexus relative to wild-type retinas, indicating a delay in retinal angiogenesis
• at P5, growth of the retinal vascular plexus is delayed to a greater extent than in mice homozygous for Notch4tm1(KOMP)Vlcg allele
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• P5 retinas show a 18.7% reduction in total vessel length relative to wild-type retinas
• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal
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vision/eye
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• P5 retinas show a 17.4% reduction in the area covered by the vascular plexus relative to wild-type retinas, indicating a delay in retinal angiogenesis
• at P5, growth of the retinal vascular plexus is delayed to a greater extent than in mice homozygous for Notch4tm1(KOMP)Vlcg allele
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• P5 retinas show a 18.7% reduction in total vessel length relative to wild-type retinas
• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal
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Allelic
Composition |
Notch4tm1Grid/Notch4+
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Genetic
Background |
involves: 129S1/Sv * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch4tm1Grid mutation
(2 available);
any
Notch4 mutation
(87 available)
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cardiovascular system
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• P5 retinas show a 18.0% reduction in the area covered by the vascular plexus relative to wild-type retinas
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• P5 retinas show a 16.9% reduction in total vessel length relative to wild-type retinas
• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal
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vision/eye
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• P5 retinas show a 18.0% reduction in the area covered by the vascular plexus relative to wild-type retinas
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• P5 retinas show a 16.9% reduction in total vessel length relative to wild-type retinas
• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm1Grid mutation
(0 available);
any
Notch1 mutation
(115 available)
Notch4tm1Grid mutation
(2 available);
any
Notch4 mutation
(87 available)
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growth/size/body
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• normal size at birth but weight was only about 80% that of controls at 3 weeks of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm1Grid mutation
(0 available);
any
Notch1 mutation
(115 available)
Notch4tm1Grid mutation
(2 available);
any
Notch4 mutation
(87 available)
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embryo
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• embryonic blood vessels fail to invade trophoblast
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• pale yolk sacs lacking obvious blood vessels
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• did not complete embryonic turning
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• pale yolk sacs lacking obvious blood vessels
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cardiovascular system
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• dorsal aortae lack lumens
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• severely disorganized intersomitic vessels
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• embryonic blood vessels fail to invade trophoblast
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• vasculogenesis was normal but subsequent remodeling failed
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• pale yolk sacs lacking obvious blood vessels
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• anterior cardinal veins discontinuous or missing
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nervous system
homeostasis/metabolism
Analysis Tools