All Phenotypes Erbb2<tm1Cbm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Erbb2^tm1Cbm
targeted mutation 1, Carmen Birchmeier
MGI:1929071

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbb2^tm1Cbm/Erbb2^tm1Cbm	involves: 129P2/OlaHsd * C57BL/6	MGI:2175861
ht2	Erbb2^tm1Cbm/Erbb2⁺	involves: 129P2/OlaHsd	MGI:3530783
ht3	Erbb2^tm1Cbm/Erbb2^tm2.1Cbm	involves: 129P2/OlaHsd * C57BL/6	MGI:2177310
cn4	Egr2^tm2(cre)Pch/Egr2⁺ Erbb2^tm1Cbm/Erbb2^tm2Cbm	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:2177311
cn5	Erbb2^tm1Cbm/Erbb2^tm2Cbm Myl2^tm1(cre)Krc/Myl2⁺	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:3621567
cx6	Erbb2^tm1Cbm/Erbb2⁺ Nrg1^tm1Cbm/Nrg1⁺	involves: 129P2/OlaHsd	MGI:3530776
cx7	Erbb2^tm1Cbm/Erbb2⁺ Erbb3^tm2Cbm/Erbb3⁺ Nrg1^tm1Cbm/Nrg1⁺	involves: 129P2/OlaHsd	MGI:3530779

Allelic Composition	Erbb2^tm1Cbm/Erbb2^tm1Cbm
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Cbm mutation (0 available); any Erbb2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:48515 )

• die by E10.75

cardiovascular system

absent trabeculae carneae ( J:48515 )

nervous system

abnormal sympathetic ganglion morphology ( J:48515 )

decreased Schwann cell precursor number ( J:48515 )

• numbers of early Schwann cell precursors that accompany projections of sensory and motor neurons are reduced at E10.5

decreased neuronal precursor cell number ( J:48515 )

• severe reduction of neuronal precursors present in the primary sympathetic ganglion chain

• reduction of precursors of sympathetic neurons

abnormal cranial ganglia morphology ( J:48515 )

• abnormal appearance of cranial ganglia

muscle

absent trabeculae carneae ( J:48515 )

embryo

abnormal neural crest cell migration ( J:48515 )

• neural crest cells are scarce at positions ventral of the neural tube and lateral of the dorsal aorta and accumulate at dorsal positions

cellular

abnormal neural crest cell migration ( J:48515 )

• neural crest cells are scarce at positions ventral of the neural tube and lateral of the dorsal aorta and accumulate at dorsal positions

Allelic Composition	Erbb2^tm1Cbm/Erbb2⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Cbm mutation (0 available); any Erbb2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:90038 )

N	• no decrease in myelin thickness was observed on the sciatic nerve

Allelic Composition	Erbb2^tm1Cbm/Erbb2^tm2.1Cbm
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Cbm mutation (0 available); any Erbb2 mutation (59 available)
Erbb2^tm2.1Cbm mutation (0 available); any Erbb2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:75421 )

• die before E11.5

cardiovascular system

absent trabeculae carneae ( J:75421 )

nervous system

abnormal sympathetic ganglion morphology ( J:75421 )

• abnormal cranial sensory ganglia

muscle

absent trabeculae carneae ( J:75421 )

Allelic Composition	Egr2^tm2(cre)Pch/Egr2⁺ Erbb2^tm1Cbm/Erbb2^tm2Cbm
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr2^tm2(cre)Pch mutation (2 available); any Egr2 mutation (31 available)
Erbb2^tm1Cbm mutation (0 available); any Erbb2 mutation (59 available)
Erbb2^tm2Cbm mutation (0 available); any Erbb2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:75421 )

• 5 of 37 die within 6 months

behavior/neurological

abnormal locomotor activation ( J:75421 )

• difficulties in hindlimb movement

abnormal gait ( J:75421 )

• gait abnormalities

growth/size/body

cachexia ( J:75421 )

• display wasting associated with weight loss and premature death

limbs/digits/tail

kinked tail ( J:75421 )

• kinked or serpentine tails

nervous system

decreased Schwann cell number ( J:75421 )

• at P3.5, see a 10-fold reduction in ventral and a 5-fold reduction in dorsal roots, with this reduction still apparent at P15, however by 6 months of age, cell numbers are similar to those in controls, however myelin sheaths formed are thin

abnormal myelin sheath morphology ( J:75421 )

• reduction in thickness of the myelin sheath of sciatic nerves at P15 that persists at 6 and 14 months of age

• thin myelin is due to the presence of fewer wraps of myelin around the axon

abnormal dorsal spinal root morphology ( J:75421 )

• dorsal roots display a severe decrease of Schwann cells in all mutants at P3.5 and P15

abnormal sciatic nerve morphology ( J:75421 )

• sciatic nerves at P15 are translucent and thin

abnormal ventral spinal root morphology ( J:75421 )

• ventral roots display a severe decrease of Schwann cells in all mutants at P3.5 and P15

• about 20% loss of axons in the L5 ventral root

abnormal myelination ( J:75421 )

• hypomyelination in sciatic, sural, saphenous nerves, nerves innervating lower leg muscles, and the dorsal spinal roots and absent myelin in ventral spinal roots

• occasionally see large-caliber axons lacking myelin that are still surrounded by a Schwann cell basal lamina in the sciatic nerve

Allelic Composition	Erbb2^tm1Cbm/Erbb2^tm2Cbm Myl2^tm1(cre)Krc/Myl2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Cbm mutation (0 available); any Erbb2 mutation (59 available)
Erbb2^tm2Cbm mutation (0 available); any Erbb2 mutation (59 available)
Myl2^tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:77347 )

• 27% die before reaching 6 months of age and 20% die during echochardiographic or ECG examination

postnatal lethality, incomplete penetrance ( J:77347 )

• 16% die within the first 2 weeks, the rest reach adulthood

cardiovascular system

abnormal myocardial fiber morphology ( J:77347 )

• adults and 3 month old mice exhibit myofiber hypertrophy

• frequently observe enlarged cardiomyocyte nuclei with abnormal morphology

cardiac hypertrophy ( J:77347 )

• heart-to-body weight ratios of adults are increased by 26%, indicative of hypertrophy

increased heart ventricle size ( J:77347 )

• adults exhibit enlarged ventricular chambers

thin ventricular wall ( J:77347 )

• seen in adults

dilated cardiomyopathy ( J:77347 )

• progressive malfunction of the heart

decreased ventricle muscle contractility ( J:77347 )

• at 1 month of age, see dilatation and loss of left ventricle contractility

• at 3 months of age, ventricular diameter is increased and fractional shortening is impaired

• hearts do not compensate after aortic banding but display a further decrease in fractional shortening

prolonged QT interval ( J:77347 )

• significantly lengthened QT_c interval caused by a slowed ventricular repolarization

muscle

abnormal myocardial fiber morphology ( J:77347 )

• adults and 3 month old mice exhibit myofiber hypertrophy

• frequently observe enlarged cardiomyocyte nuclei with abnormal morphology

dilated cardiomyopathy ( J:77347 )

• progressive malfunction of the heart

decreased ventricle muscle contractility ( J:77347 )

• at 1 month of age, see dilatation and loss of left ventricle contractility

• at 3 months of age, ventricular diameter is increased and fractional shortening is impaired

• hearts do not compensate after aortic banding but display a further decrease in fractional shortening

growth/size/body

cardiac hypertrophy ( J:77347 )

• heart-to-body weight ratios of adults are increased by 26%, indicative of hypertrophy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:77347

Allelic Composition	Erbb2^tm1Cbm/Erbb2⁺ Nrg1^tm1Cbm/Nrg1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Cbm mutation (0 available); any Erbb2 mutation (59 available)
Nrg1^tm1Cbm mutation (0 available); any Nrg1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal myelination ( J:90038 )

• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age

abnormal nerve conduction ( J:90038 )

• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials

Allelic Composition	Erbb2^tm1Cbm/Erbb2⁺ Erbb3^tm2Cbm/Erbb3⁺ Nrg1^tm1Cbm/Nrg1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Cbm mutation (0 available); any Erbb2 mutation (59 available)
Erbb3^tm2Cbm mutation (0 available); any Erbb3 mutation (47 available)
Nrg1^tm1Cbm mutation (0 available); any Nrg1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal myelination ( J:90038 )

• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age

abnormal nerve conduction ( J:90038 )

• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials

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