Phenotypes associated with this allele

• Allele Symbol: Pcgf2⁺
• Allele Name: wild type
• Allele ID: MGI:1928649
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pcgf2^tm1b(KOMP)Mbp/Pcgf2^+	C57BL/6N-Pcgf2^tm1b(KOMP)Mbp/Tcp	MGI:5797699
ht2	Pcgf2^tm1Hko/Pcgf2^+	involves: C57BL/6	MGI:3574651
cx3	Pcgf2^tm1Hko/Pcgf2^+ Bmi1^tm1Brn/Bmi1^tm1Brn	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3577618
cx4	Pcgf2^tm1Hko/Pcgf2^+ Sf3b1^tm1Hko/Sf3b1^+	involves: C57BL/6	MGI:3574652

Genotype
MGI:5797699

ht1

• Allelic Composition: Pcgf2^{tm1b(KOMP)Mbp}/Pcgf2⁺
• Genetic Background: C57BL/6N-Pcgf2^{tm1b(KOMP)Mbp}/Tcp
• Cell Lines: DEPD00539_2_E06

Data Sources

IMPC Data for Pcgf2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

small testis ( J:211773 )

♂

IMPC - UCD

hematopoietic system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

small spleen ( J:211773 )

♀

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

small spleen ( J:211773 )

♀

IMPC - UCD

reproductive system

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

small testis ( J:211773 )

♂

IMPC - UCD

skeleton

abnormal lumbar vertebrae morphology ( J:211773 )

IMPC - UCD

increased bone mineral content ( J:211773 )

♀

IMPC - UCD

Genotype
MGI:3574651

ht2

• Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺
• Genetic Background: involves: C57BL/6

skeleton

thoracic vertebral transformation ( J:96358 )

• 11% exhibit T1 to T2 transformation

• 28% exhibit T13 to L1 transformation

cervical vertebral transformation ( J:96358 )

• 6% exhibit C7 to T1 transformation

lumbar vertebral transformation ( J:96358 )

• 89% exhibit L6 to S1 transformation compared to 62% in wildtype

Genotype
MGI:3577618

cx3

• Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺; Bmi1^tm1Brn/Bmi1^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

craniofacial

abnormal craniofacial bone morphology ( J:68216 )

split exoccipital bone ( J:68216 )

cleft secondary palate ( J:68216 )

skeleton

abnormal scapula morphology ( J:68216 )

acromion hypoplasia ( J:68216 )

• acromion is poorly formed

scapular bone foramen ( J:68216 )

• holes are seen in the blade of the scapula

abnormal axial skeleton morphology ( J:68216 )

abnormal craniofacial bone morphology ( J:68216 )

split exoccipital bone ( J:68216 )

abnormal rib joint morphology ( J:68216 )

• rudimentary ribs attached to C6

abnormal cervical atlas morphology ( J:68216 )

• atlas resembles the third cervical vertebra

cervical vertebral transformation ( J:68216 )

• atlas resembles the third cervical vertebra

abnormal sternum ossification ( J:68216 )

• ectopic ossification centers in sternum

digestive/alimentary system

cleft secondary palate ( J:68216 )

growth/size/body

cleft secondary palate ( J:68216 )

Genotype
MGI:3574652

cx4

• Allelic Composition: Pcgf2^tm1Hko/Pcgf2⁺; Sf3b1^tm1Hko/Sf3b1⁺
• Genetic Background: involves: C57BL/6

skeleton

abnormal sternocostal joint morphology ( J:96358 )

• the detachment of the ribs of T7 from the sternum, representing an anterior shift of the sternum of one segment width

vertebral transformation ( J:96358 )

thoracic vertebral transformation ( J:96358 )

• 75% exhibit T1 to T2 transformation

• 50% exhibit T13 to L1 transformation

cervical vertebral transformation ( J:96358 )

• 45% exhibit C7 to T1 transformation, and showed ectopic ribs associated with C7 mimicking perfect ribs and forming joints with the anteriorly shifted sternum

lumbar vertebral transformation ( J:96358 )

• 100% exhibit an L6 to S1 transformation

abnormal sternum ossification ( J:96358 )

• the formation of an additional ossification center in the sternum