Phenotypes associated with this allele

• Allele Symbol: Ppard^tm1Jps
• Allele Name: targeted mutation 1, Jeffrey M Peters
• Allele ID: MGI:1889516
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppard^tm1Jps/Ppard^tm1Jps	involves: 129/Sv * C57BL/6N	MGI:3510234
cx2	Apc^Min/Apc^+ Ppard^tm1Jps/Ppard^tm1Jps	involves: 129/Sv * AKR/J * C57BL/6 * C57BL/6J	MGI:3510235

Genotype
MGI:3510234

hm1

• Allelic Composition: Ppard^tm1Jps/Ppard^tm1Jps
• Genetic Background: involves: 129/Sv * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:63040 )

• seen only when the C57BL/6N contribution to the genetic background was around 50%

neoplasm

increased tumor incidence ( J:90337 )

increased intestinal adenocarcinoma incidence ( J:90217 )

• colon cancer resulting from treatment with azoxymethane is more severe and mortality occurs earlier than in controls

increased sebaceous gland adenoma incidence ( J:90337 )

• occasional mice develop sebaceous gland adenomas

increased incidence of tumors by chemical induction ( J:90217 , J:90337 )

• colon cancer resulting from treatment with azoxymethane is more severe and mortality occurs earlier than in controls (J:90217)

• homozygotes respond more quickly to inducing agents with more and larger sized papillomas (J:90337)

increased skin tumor incidence ( J:90337 )

• occasional mice develop sebaceous gland adenomas and keratocanthomas

increased skin papilloma incidence ( J:90337 )

• homozygotes respond more quickly to inducing agents with more and larger sized papillomas

adipose tissue

increased total body fat amount ( J:89827 )

• increased adiposity on a high fat diet

abnormal gonadal fat pad morphology ( J:63040 )

• smaller than normal gonadal fat stores before 48 weeks of age but not after

growth/size/body

decreased body size ( J:63040 )

• although postnatal development was normal, mice were significantly smaller from 3 days of age to 48 weeks, particularly females

decreased fetal size ( J:63040 )

• crown to rump length was shorter than normal at E18

homeostasis/metabolism

abnormal energy expenditure ( J:63040 )

• energy consumption by males is greater than in controls

abnormal lipid level ( J:76564 )

• females show a shift in the composition of phospholipids in the brain

increased circulating VLDL cholesterol level ( J:89827 )

• rate of VLDL production in the liver is increased

increased circulating triglyceride level ( J:89827 )

• elevated plasma triglycerides on both normal and high fat diet

decreased liver cholesterol level ( J:89827 )

• on a high fat diet, cholesterol is depleted in the liver

increased fatty acids level ( J:89827 )

• on both normal and high fat diet

decreased liver triglyceride level ( J:89827 )

• on a high fat diet, triglycerides are depleted in the liver

increased incidence of tumors by chemical induction ( J:90217 , J:90337 )

• colon cancer resulting from treatment with azoxymethane is more severe and mortality occurs earlier than in controls (J:90217)

• homozygotes respond more quickly to inducing agents with more and larger sized papillomas (J:90337)

immune system

skin inflammation ( J:63040 )

• increased inflammatory response in the skin

liver/biliary system

decreased liver cholesterol level ( J:89827 )

• on a high fat diet, cholesterol is depleted in the liver

decreased liver triglyceride level ( J:89827 )

• on a high fat diet, triglycerides are depleted in the liver

nervous system

abnormal brain morphology ( J:63040 )

decreased brain size ( J:63040 )

• significantly smaller brain diameter

abnormal myelination ( J:63040 )

• altered myelination in the corpus callosum but not in other brain regions

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:90217 )

• colon cancer resulting from treatment with azoxymethane is more severe and mortality occurs earlier than in controls

intestine polyps ( J:90217 )

• increased numbers of small intestine polyps as well in females

integument

increased sebaceous gland adenoma incidence ( J:90337 )

• occasional mice develop sebaceous gland adenomas

skin inflammation ( J:63040 )

• increased inflammatory response in the skin

epidermal hyperplasia ( J:63040 )

• greater response to induced hyperplasia

increased skin tumor incidence ( J:90337 )

• occasional mice develop sebaceous gland adenomas and keratocanthomas

increased skin papilloma incidence ( J:90337 )

• homozygotes respond more quickly to inducing agents with more and larger sized papillomas

endocrine/exocrine glands

increased sebaceous gland adenoma incidence ( J:90337 )

• occasional mice develop sebaceous gland adenomas

Genotype
MGI:3510235

cx2

• Allelic Composition: Apc^Min/Apc⁺; Ppard^tm1Jps/Ppard^tm1Jps
• Genetic Background: involves: 129/Sv * AKR/J * C57BL/6 * C57BL/6J

neoplasm

increased intestinal adenocarcinoma incidence ( J:90337 )

• colon cancer is more severe and mortality occurs earlier than in controls

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:90337 )

• colon cancer is more severe and mortality occurs earlier than in controls

intestine polyps ( J:90337 )

• increased numbers of small intestine polyps as well in females