All Phenotypes Tapbp<tm1Luc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tapbp^tm1Luc
targeted mutation 1, Luc van Kaer
MGI:1888941

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tapbp^tm1Luc/Tapbp^tm1Luc	involves: 129S6/SvEvTac	MGI:3714648
hm2	Tapbp^tm1Luc/Tapbp^tm1Luc	involves: 129S6/SvEvTac * C57BL/6	MGI:3714619
cx3	Tapbp^tm1Luc/Tapbp^tm1Luc Tg(TcraTcrb)1100Mjb/?	involves: 129S6/SvEvTac	MGI:3714650
cx4	Tapbp^tm1Luc/Tapbp^tm1Luc Tg(TcraTcrb)1100Mjb/?	involves: 129S6/SvEvTac * C57BL/6	MGI:3714649

Allelic Composition	Tapbp^tm1Luc/Tapbp^tm1Luc
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tapbp^tm1Luc mutation (1 available); any Tapbp mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD8-positive, alpha-beta T cell number ( J:64177 )

• mice have few (15-20% of wild-type) mature CD8+ T cells in the periphery, but significantly more than Tap1-null animals

abnormal cytotoxic T cell physiology ( J:64177 )

• mice mount poor CTL responses to influenza virus, but normal responses to LCMV and vaccinia viruses

abnormal antigen presentation via MHC class I ( J:64177 )

• cells infected with an influenza virus or a vaccinia virus minigene encoding an ovalbumin peptide were poorly recognized by nucleoprotein-specific D^b-restricted T cell hybridoma or by cytotoxic T lymphocytes, respectively

decreased level of surface class I molecules ( J:64177 )

• expression is 10-15% of that observed on wild-type cells, or 2 times the level on Tap1-deficient cells

defective assembly of class I molecules ( J:64177 )

• mice display defective assembly of class I peptide-loading complexes

• in null cells, most heavy chains are thermolabile indicating lack of high-affinity peptides; most MHC class I molecules lack high-affinity peptides but traffic normally to the cell surface

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:64177 )

• mice have few (15-20% of wild-type) mature CD8+ T cells in the periphery, but significantly more than Tap1-null animals

abnormal cytotoxic T cell physiology ( J:64177 )

• mice mount poor CTL responses to influenza virus, but normal responses to LCMV and vaccinia viruses

Allelic Composition	Tapbp^tm1Luc/Tapbp^tm1Luc
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tapbp^tm1Luc mutation (1 available); any Tapbp mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal lymphocyte physiology ( J:122479 )

• decay of surface K^b and D^b molecules on brefeldin A-treated cells is increased compared to wild-type and Arts1-null cells

hematopoietic system

abnormal lymphocyte physiology ( J:122479 )

• decay of surface K^b and D^b molecules on brefeldin A-treated cells is increased compared to wild-type and Arts1-null cells

Allelic Composition	Tapbp^tm1Luc/Tapbp^tm1Luc Tg(TcraTcrb)1100Mjb/?
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tapbp^tm1Luc mutation (1 available); any Tapbp mutation (23 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:64177 )

N	• mice show normal T cell development, including normal positive selection

Allelic Composition	Tapbp^tm1Luc/Tapbp^tm1Luc Tg(TcraTcrb)1100Mjb/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tapbp^tm1Luc mutation (1 available); any Tapbp mutation (23 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal negative T cell selection ( J:64177 )

• double-negative thymocytes are allowed to progress to double- and single-positive stages, indicating defective negative selection

abnormal positive T cell selection ( J:64177 )

• also observed to be defective

abnormal CD4-positive, alpha beta T cell morphology ( J:64177 )

• female mice have increased numbers of CD4+CD8- T cells not expressing the transgene in the lymph node and thymus

• male mutants also show skewing toward CD4+ lineage

abnormal CD8-positive, alpha beta T cell morphology ( J:64177 )

• female mice have substantially reduced numbers of CD4-CD8+ H-Y TCR+ cells in thymus and periphery compared to controls

immune system

immune system phenotype ( J:64177 )

N	• male mutants have normal-sized thymuses, whereas Tapbp-sufficient, transgenic males have a small thymus

abnormal negative T cell selection ( J:64177 )

• double-negative thymocytes are allowed to progress to double- and single-positive stages, indicating defective negative selection

abnormal positive T cell selection ( J:64177 )

• also observed to be defective

abnormal CD4-positive, alpha beta T cell morphology ( J:64177 )

• female mice have increased numbers of CD4+CD8- T cells not expressing the transgene in the lymph node and thymus

• male mutants also show skewing toward CD4+ lineage

abnormal CD8-positive, alpha beta T cell morphology ( J:64177 )

• female mice have substantially reduced numbers of CD4-CD8+ H-Y TCR+ cells in thymus and periphery compared to controls

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