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Allele Symbol Allele Name Allele ID |
Nf2tm1Gth targeted mutation 1, Gilles Thomas MGI:1888776 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 13% of mice exhibit fibroadenoma in the mammary gland
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• 13% of mice exhibit fibroadenoma in the mammary gland
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• mice exhibit osseous metaplasia in the lung, brain, kidney, and nasal mucosa
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• 6% of mice develop neurofibroma
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• in 56% in mice
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• 6% of mice develop anaplastic carcinoma in the kidney
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• 13% of mice develop carcino-sarcoma in the mammary gland
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• 6% of mice develop neurofibrosarcoma with 2 of 7 metastasizing to the liver
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• in 44% of mice
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• 6% of mice develop mesothelioma
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• 50% of mice develop osteoma
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• 13% of mice exhibit fibroadenoma in the mammary gland
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• 6% of mice exhibit odontoblastic hyperplasia
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• in 44% of mice
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• 50% of mice develop osteoma
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• osteoblastic hyperplasia in 44% of mice
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• 6% of mice develop anaplastic carcinoma in the kidney
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• 38% of mice exhibit renal tubular cell hyperplasia
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• in 56% in mice
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| N |
• mice exhibit normal Schwann cell proliferation
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• 6% of mice develop neurofibroma
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• 6% of mice develop neurofibrosarcoma with 2 of 7 metastasizing to the liver
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• 6% of mice exhibit odontoblastic hyperplasia
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• 6% of mice exhibit odontoblastic hyperplasia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit reduced viability
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• mice exhibit osseous metaplasia in the lung, brain, kidney, and nasal mucosa
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• one mouse developed a mesothelioma
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• 9% of mice develop odontomas and odontosarcomas
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• 9% of mice develop odontomas and odontosarcomas
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• mice develop Schwann cell tumors
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• mice exhibit odontoblastic hyperplasia
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• osteoblastic hyperplasia
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• mice develop Schwann cell tumors
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• 59% of mice exhibit Schwann cell hyperplasia
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• mice exhibit renal tubular cell hyperplasia
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• mice exhibit odontoblastic hyperplasia
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• mice exhibit odontoblastic hyperplasia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% of mice die within the first year
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• retarded or absent
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• retarded or absent
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• retarded or absent
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• retarded or absent
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• retarded or absent
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• retarded or absent
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| otitis media | DOID:10754 | J:63264 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the few mice that are produced die prior to weaning
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• at P17, one mouse exhibited a subcutaneous Schwann cell nodule
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• at P19, one mouse exhibited a hamartoma of the olfactory bulb composed of Schwann and neural cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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