Analysis Tools
homeostasis/metabolism
|
• retinas have a selective deficit of 22:6,n-3-containing phospholipids and very long-chain polyunsaturated fatty acids
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nervous system
|
• progressive degeneration of rods and cones as detected by electroretinogram; age of onset is approximately 1 month
|
vision/eye
|
• Relative to C57BL/6J controls, homozygotes develop a smaller posterior eye and shorter posterior chamber depth leading to a shorter axial length, although the anterior chamber depth is longer, and decreased corneal radius of curvature
|
|
• progressive degeneration of rods and cones as detected by electroretinogram; age of onset is approximately 1 month
|
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• loss of outer nuclear layer progresses more quickly with age than does that of C57BL/6J controls
|
|
• age of onset is approximately 7 months
(J:64087)
• decreased retinal thickness and outer nuclear later thickness with age relative to C57BL/6J controls, and increased Muller glia by 4 months of age
(J:364267)
|
retina spots
(
J:64087
)
|
• subretinal spots oriented in a regular pattern across the retina are apparent by ophthalmoscopic examination at approximately 8-10 weeks of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| fundus albipunctatus | DOID:11105 |
OMIM:136880 |
J:64087 | |
