Phenotypes associated with this allele

• Allele Symbol: Hbb^tm2Unc
• Allele Name: targeted mutation 2, University of North Carolina
• Allele ID: MGI:1888408
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hbb^tm2Unc/Hbb^tm2Unc	involves: 129P2/OlaHsd * C57BL/6J	MGI:3835307
ht2	Hbb^tm2Unc/Hbb^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3835308

Genotype
MGI:3835307

hm1

• Allelic Composition: Hbb^tm2Unc/Hbb^tm2Unc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:64295 )

• mice are born but fail to survive postnatally

growth/size/body

decreased birth body size ( J:64295 )

• reduced body size at birth

integument

pallor ( J:64295 )

• at birth

Genotype
MGI:3835308

ht2

• Allelic Composition: Hbb^tm2Unc/Hbb⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

hematopoietic system

enlarged spleen ( J:64295 )

• 2% of body weight compared to 0.2% in wild-type mice

extramedullary hematopoiesis ( J:64295 )

• in the liver

abnormal erythrocyte morphology ( J:64295 )

decreased erythrocyte cell number ( J:64295 )

decreased hematocrit ( J:64295 )

increased hemoglobin concentration distribution width ( J:64295 )

decreased hemoglobin content ( J:64295 )

increased mean corpuscular hemoglobin concentration ( J:64295 )

decreased mean corpuscular volume ( J:64295 )

anisocytosis ( J:64295 )

poikilocytosis ( J:64295 )

increased spleen iron level ( J:64295 )

• by 5 months of age

liver/biliary system

increased liver iron level ( J:64295 )

• by 5 months of age

renal/urinary system

increased kidney iron level ( J:64295 )

• greater than in wild-type mice by 5 months of age

homeostasis/metabolism

increased spleen iron level ( J:64295 )

• by 5 months of age

increased kidney iron level ( J:64295 )

• greater than in wild-type mice by 5 months of age

increased liver iron level ( J:64295 )

• by 5 months of age

immune system

enlarged spleen ( J:64295 )

• 2% of body weight compared to 0.2% in wild-type mice

increased spleen iron level ( J:64295 )

• by 5 months of age

growth/size/body

enlarged spleen ( J:64295 )

• 2% of body weight compared to 0.2% in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
beta thalassemia		DOID:12241	OMIM:613985	J:64295