All Phenotypes Fbxo11<Jf> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxo11^Jf/Fbxo11^Jf	involves: BALB/cAnNCrl * C3H/HeN	MGI:3693667
ht2	Fbxo11^Jf/Fbxo11⁺	involves: BALB/cAnNCrl	MGI:6102909
ht3	Fbxo11^Jf/Fbxo11⁺	involves: BALB/cAnNCrl * C3H/HeN	MGI:3526564
ht4	Fbxo11^Jf/Fbxo11⁺	involves: BALB/cAnNCrl * C3H/HeN * C57BL/6J	MGI:3693665
ht5	Fbxo11^Jf/Fbxo11^Mutt	involves: BALB/c * C3H/HeN	MGI:3693680

Allelic Composition	Fbxo11^Jf/Fbxo11^Jf
Genetic Background	involves: BALB/cAnNCrl * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo11^Jf mutation (2 available); any Fbxo11 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:114851 )

• one hundred percent of homozygotes died at birth or within a few hours due to respiratory problems

vision/eye

eyelids open at birth ( J:114851 )

• born with upper eyelids open

craniofacial

cleft palate ( J:114851 )

• clefting of the hard or soft palate

midline facial cleft ( J:114851 )

digestive/alimentary system

cleft palate ( J:114851 )

• clefting of the hard or soft palate

growth/size/body

cleft palate ( J:114851 )

• clefting of the hard or soft palate

midline facial cleft ( J:114851 )

Allelic Composition	Fbxo11^Jf/Fbxo11⁺
Genetic Background	involves: BALB/cAnNCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo11^Jf mutation (2 available); any Fbxo11 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:250208 )

N	• mice exhibit normal inner ear morphology

middle ear effusion ( J:250208 )

middle ear polyps ( J:250208 )

• edematous polyps projecting into the middle ear cavity

impaired hearing ( J:250208 )

• poor performance to the click-box

increased susceptibility to otitis media ( J:250208 )

• chronic suppurative with a granulocytic effusion and a thickened mucoperisoteum

behavior/neurological

abnormal pinna reflex ( J:250208 )

• poor performance to the click-box

homeostasis/metabolism

middle ear effusion ( J:250208 )

immune system

increased susceptibility to otitis media ( J:250208 )

• chronic suppurative with a granulocytic effusion and a thickened mucoperisoteum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:250208

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

middle ear effusion ( J:85263 )

• middle ear effusion of varying density and composition

behavior/neurological

absent pinna reflex ( J:85263 )

• absent Preyer response in clickbox test

craniofacial

abnormal middle ear ossicle morphology ( J:85263 )

• middle ear bony wall appeared thicker in mutants

short snout ( J:85263 )

• short snout and occipital region, indicating mild craniofacial defects

excessive cerumen ( J:85263 )

• at 11 months of age, the external ear was filled with cerumen

growth/size/body

short snout ( J:85263 )

• short snout and occipital region, indicating mild craniofacial defects

excessive cerumen ( J:85263 )

• at 11 months of age, the external ear was filled with cerumen

decreased body size ( J:85263 )

decreased body weight ( J:85263 )

• heterozygous mice weigh 21% smaller than controls

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:85263 )

N	• normal middle ear ossicles and inner ear • no significant hair cell degeneration was observed up to 18 months of age • no perforations of the tympanic membrane

abnormal middle ear ossicle morphology ( J:85263 )

• middle ear bony wall appeared thicker in mutants

excessive cerumen ( J:85263 )

• at 11 months of age, the external ear was filled with cerumen

abnormal auditory tube morphology ( J:85263 )

• in neonates, the lumen of eustachean tube is smaller with a disrupted epithelial lining; the lumen may contain cellular debris

• the adult eustachean tube was narrower and was bent compared to controls

abnormal tympanic cavity morphology ( J:85263 )

• papillary to polypoid growths in the tympanic cavity

• evidence of inflammatory and fibroblast infiltration

• the middle ear cavity in some neonates had collapsed; in adults, the cavity appeared to be reduced in size

middle ear effusion ( J:85263 )

• middle ear effusion of varying density and composition

tympanic membrane retraction ( J:85263 )

• at 11 months of age, tympanic membrane retraction was evident with calcification in the middle ear

middle ear polyps ( J:85263 )

• papillary to polypoid growths in the tympanic cavity

decreased endocochlear potential ( J:85263 )

• low endocochlear potentials suggesting impaired strial function

deafness ( J:63816 , J:85263 )

• fully penetrant at 4 weeks of age (J:85263)

increased susceptibility to otitis media ( J:85263 )

• chronic proliferative otitis media at moderate severity; included effusion of varying density and composition

immune system

increased susceptibility to otitis media ( J:85263 )

• chronic proliferative otitis media at moderate severity; included effusion of varying density and composition

abnormal cytokine secretion ( J:85263 )

• TNFalpha, IL1beta, and IL8 were all present in middle ear effusions

skeleton

abnormal middle ear ossicle morphology ( J:85263 )

• middle ear bony wall appeared thicker in mutants

Allelic Composition	Fbxo11^Jf/Fbxo11⁺
Genetic Background	involves: BALB/cAnNCrl * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo11^Jf mutation (2 available); any Fbxo11 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased susceptibility to otitis media ( J:114851 )

• otitis media was clearly evident by 28 days of age onwards

• no cleft palate was observed at any stage

immune system

increased susceptibility to otitis media ( J:114851 )

• otitis media was clearly evident by 28 days of age onwards

• no cleft palate was observed at any stage

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:114851

Allelic Composition	Fbxo11^Jf/Fbxo11^Mutt
Genetic Background	involves: BALB/c * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxo11^Jf mutation (2 available); any Fbxo11 mutation (51 available)
Fbxo11^Mutt mutation (0 available); any Fbxo11 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:114851 )

• a small proportion (12%) of compound heterozygous showed perinatal lethality similar to Fbxo11^Jf/Fbxo11^Jf or similar to Fbxo11^Mutt/Fbxo11^Mutt

hearing/vestibular/ear

impaired hearing ( J:114851 )

• reduced hearing in response to a click box similar to Fbxo11^Jf heterozygotes

increased susceptibility to otitis media ( J:114851 )

• similar to Fbxo11^Jf/Fbxo11⁺

immune system

increased susceptibility to otitis media ( J:114851 )

• similar to Fbxo11^Jf/Fbxo11⁺

craniofacial

short face ( J:114851 )

• shortened face similar to Fbxo11^Jf/Fbxo11⁺

midline facial cleft ( J:114851 )

• in some similar to Fbxo11^Jf/Fbxo11^Jf or similar to Fbxo11^Mutt/Fbxo11^Mutt

growth/size/body

short face ( J:114851 )

• shortened face similar to Fbxo11^Jf/Fbxo11⁺

midline facial cleft ( J:114851 )

• in some similar to Fbxo11^Jf/Fbxo11^Jf or similar to Fbxo11^Mutt/Fbxo11^Mutt

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:114851

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23