Analysis Tools
mortality/aging
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• no homozygote embryos are present at E10.5 and the lack of resorbed embryos suggests that lethality occurs before implantation
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Allele Symbol Allele Name Allele ID |
Krd kidney and retinal defects MGI:1861657 |
| Summary |
2 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no homozygote embryos are present at E10.5 and the lack of resorbed embryos suggests that lethality occurs before implantation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: the expected 50% transgenic offspring are observed at weaning when the founder mice are crossed with C57BL/6
• Background Sensitivity: the percentage of transgenic offspring fall in subsequent backcrosses to C57BL/6 with 35% being transgenic in the 2nd backcross, 19% being transgenic in the 3rd backcross, and 11% being transgenic in the 4th
• Background Sensitivity: lethality in the backcrosses to C57BL/6 occurs in the late fetal or early postnatal stage with at least some of the mice dying from kidney aplasia
• Background Sensitivity: percentages of transgenic offspring are closer to expected rates when founder mice are crossed with C3H/HeJ mice with 46% being transgenic in the 2nd backcross and 42% being transgenic in the 3rd backcross
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• the growth of these mice is retarded for the first 2 months of birth being about 80% of littermate controls
• normal weight is eventually reached
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• unilateral kidney cysts are common in these mice
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• unilateral kidney cysts are common in these mice
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• the thickness of the cortical tissue is decreased due in part to less numbers of glomeruli and a smaller profile of proximal convoluted tubules
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• immature mesenchymal tissue is more prominent at the corticomedullary junction
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• the nephrogenic zone is attenuated and disorganized
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• kidneys from these mice demonstrate considerable immaturity compared with wild-type mice
• the nephrogenic zone is attenuated and disorganized
• the thickness of the cortical tissue is decreased due in part to less numbers of glomeruli and a smaller profile of proximal convoluted tubules
• immature mesenchymal tissue is more prominent at the corticomedullary junction
• these immature features are still present at a lesser degree in mice 4 days old but disappear by adulthood
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• kidneys with no obvious defects weigh significantly less with a mean of 4.8 mg/g bodyweight compared to 6.2 mg/g for kidneys from littermate controls
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• the number of mature nephrons is smaller
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• kidneys were absent in one stillborn pup that occurred among 24 observed births
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• only one kidney is present in 13% of mice
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• is commonly observed
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• retinas of some mice are noticeably thinner than controls, with extreme hypocellularity occurring in different positions in the retina
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• the nuclear layers are thinner with fewer somata present than in controls
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• the nuclear layers are thinner with fewer somata present than in controls
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• all mice contain malformations of the retina
• these malformations differed between animals but include zones of narrowing, an excess of somota in a single nuclear layer, photoreceptor nuclei lying ectopically within the photoreceptor layer, and rosettes of photoreceptors enclosed between retinal layers
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• the electroretinograms of eight mice varied from three in low normal range to three that are extremely abnormal
• both a- and b- waves are abnormal in mice in affected mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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