Phenotypes associated with this allele

• Allele Symbol: Klf1^Nan
• Allele Name: neonatal anemia
• Allele ID: MGI:1861107
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf1^Nan/Klf1^Nan	involves: 101/H * C3H/HeH * PT	MGI:4819281
ht2	Klf1^Nan/Klf1^+	either: B6.Cg-Klf1^Nan or WB.Cg-Klf1^Nan	MGI:4819280
ht3	Klf1^Nan/Klf1^+	involves: 101/H * C3H/HeH * PT	MGI:4819283

Genotype
MGI:4819281

hm1

• Allelic Composition: Klf1^Nan/Klf1^Nan
• Genetic Background: involves: 101/H * C3H/HeH * PT

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:13933 )

• die at E10-11

hematopoietic system

impaired hematopoiesis ( J:13933 )

• lack of hematopoiesis

Genotype
MGI:4819280

ht2

• Allelic Composition: Klf1^Nan/Klf1⁺
• Genetic Background: either: B6.Cg-Klf1^Nan or WB.Cg-Klf1^Nan

growth/size/body

increased spleen weight ( J:162530 )

• spleens weigh 2X those of controls

mortality/aging

postnatal lethality, incomplete penetrance ( J:162530 )

• significant numbers die before weaning

hematopoietic system

increased spleen weight ( J:162530 )

• spleens weigh 2X those of controls

abnormal erythrocyte morphology ( J:162530 )

• elevated enzyme activity

decreased erythrocyte cell number ( J:162530 )

decreased hematocrit ( J:162530 )

• substantially decreased

decreased hemoglobin content ( J:162530 )

• substantially decreased

decreased mean corpuscular hemoglobin ( J:162530 )

• hypochromia

anisocytosis ( J:162530 )

poikilocytosis ( J:162530 )

polychromatophilia ( J:162530 )

increased erythrocyte osmotic fragility ( J:162530 )

• susceptible to hemolysis

• cell membranes more fragile

immune system

increased spleen weight ( J:162530 )

• spleens weigh 2X those of controls

integument

pallor ( J:162530 )

• at birth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary spherocytosis		DOID:12971		J:162530

Genotype
MGI:4819283

ht3

• Allelic Composition: Klf1^Nan/Klf1⁺
• Genetic Background: involves: 101/H * C3H/HeH * PT

hematopoietic system

enlarged spleen ( J:13933 )

• there is evidence of hyperactive haemopoiesis

anemia ( J:13933 )

• marked anemia at birth

• persists through life

decreased erythrocyte cell number ( J:13933 )

increased nucleated erythrocyte cell number ( J:13933 )

• some cells retain their nuclei

anisocytosis ( J:13933 )

increased spleen iron level ( J:13933 )

• iron deposits are seen

renal/urinary system

increased kidney iron level ( J:13933 )

• significant iron deposits are seen in the proximal tubule

abnormal proximal convoluted tubule morphology ( J:13933 )

• iron deposits found in the proximal tubule of the kidney

immune system

enlarged spleen ( J:13933 )

• there is evidence of hyperactive haemopoiesis

increased spleen iron level ( J:13933 )

• iron deposits are seen

homeostasis/metabolism

increased spleen iron level ( J:13933 )

• iron deposits are seen

increased kidney iron level ( J:13933 )

• significant iron deposits are seen in the proximal tubule

increased liver iron level ( J:13933 )

• iron deposits are seen

liver/biliary system

increased liver iron level ( J:13933 )

• iron deposits are seen

growth/size/body

enlarged spleen ( J:13933 )

• there is evidence of hyperactive haemopoiesis