Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29Hx mutation
(1 available);
any
Rr29 mutation
(2 available)
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Skeletal phenotypes of Rr29Hx/Rr29Hx and Rr29Hxl3/Shh+ mice
limbs/digits/tail
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• preaxial polydactyly
(J:87798)
• supernumerary metacarpals, metatarsals, and digits
(J:87798)
• hemimelia caused by shortening of the radius, tibia, and talus
(J:87798)
• hindlimbs usually more affected than forelimbs
(J:87798)
• 100% preaxial polydactyly
(J:121866)
• tripharangeal digit 1
(J:121866)
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skeleton
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29Hx mutation
(1 available);
any
Rr29 mutation
(2 available)
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Macroscopic pictures of ventral hind limbs and skeletal hind limbs of Rr29Hx/Shh+ , Rr29Hx/Rr29Hx, Hm/+, Hm/Hm, and Hm/+ Rr29Hx/Shh+ mice
limbs/digits/tail
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• all four feet show preaxial polydactyly with six to eight digits
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• the bones of the extra preaxial digits tend to be fused
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• few cases show shortening of the radius
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• all show shortening of the tibia
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skeleton
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• few cases show shortening of the radius
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• all show shortening of the tibia
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Allelic Composition |
Rr29Hx/Rr29Hx
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Genetic Background |
involves: C57BL/10SnJ * DBA/2J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29Hx mutation
(1 available);
any
Rr29 mutation
(2 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29Hx mutation
(1 available);
any
Rr29 mutation
(2 available)
|
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limbs/digits/tail
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• both forefeet have preaxial polydactyly
• the polydactyly in the hind feet arises as a duplication of the terminal phalanx of either the first or fifth toe
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• in the forelimbs, one or both or neither radius are foreshortened
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• tibias are either absent or greatly reduced in size
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skeleton
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• in the forelimbs, one or both or neither radius are foreshortened
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• tibias are either absent or greatly reduced in size
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29Hx mutation
(1 available);
any
Rr29 mutation
(2 available)
|
|
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limbs/digits/tail
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• zone of polarizing activity is duplicated at anterior margin of fore- and hindlimb buds
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• a III-II-II-III-IV-V digit pattern
(J:27442)
• preaxial polydactyly
(J:87798)
• supernumerary metacarpals, metatarsals, and digits
(J:87798)
• hindlimbs usually more affected than forelimbs
(J:87798)
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• mirror-image duplication of the second and third tarsal bones
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• hemimelia caused by shortening of the radius, tibia, and talus
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skeleton
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• mirror-image duplication of the second and third tarsal bones
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homeostasis/metabolism
embryo
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• zone of polarizing activity is duplicated at anterior margin of fore- and hindlimb buds
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29Hx mutation
(1 available);
any
Rr29 mutation
(2 available)
|
|
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Macroscopic pictures of ventral hind limbs and skeletal hind limbs of Rr29Hx/Shh+ , Rr29Hx/Rr29Hx, Hm/+, Hm/Hm, and Hm/+ Rr29Hx/Shh+ mice
limbs/digits/tail
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• preaxial polydactyly and normal tibia
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Allelic Composition |
Rr29Hx/Rr29+
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Genetic Background |
involves: C57BL/10SnJ * DBA/2J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29Hx mutation
(1 available);
any
Rr29 mutation
(2 available)
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limbs/digits/tail
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• noticeable by E11-E12
• Background Sensitivity: variable penetrance
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• occurred in the forepaws
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• occurred in the hindpaws only
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skeleton
mortality/aging
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• mice dying during the neonatal period had cleft palate
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craniofacial
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• cause of death of some newborns
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digestive/alimentary system
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• cause of death of some newborns
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growth/size/body
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• cause of death of some newborns
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Macroscopic pictures of ventral hind limbs and skeletal hind limbs of Rr29Hx/Shh+ , Rr29Hx/Rr29Hx, Hm/+, Hm/Hm, and Hm/+ Rr29Hx/Shh+ mice
limbs/digits/tail
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• preaxial polydactyly with normal tibia
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• syndactyly is more severe than seen in single heterozygous Hm mutants
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• complete webbing of all hind feet digits that extend to the tip of the distal phalanges
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