All Phenotypes Trim28<tm1.2Ipc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trim28^tm1.2Ipc
targeted mutation 1.2, Pierre Chambon
MGI:1859550

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim28^tm1.2Ipc/Trim28^tm1.2Ipc	involves: 129S2/SvPas * C57BL/6	MGI:2170897
ht2	Trim28^chatwo/Trim28^tm1.2Ipc	involves: 129S2/SvPas * C57BL/6J	MGI:5620615
cn3	Trim28^tm1.1Ipc/Trim28^tm1.2Ipc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5620619

Allelic Composition	Trim28^tm1.2Ipc/Trim28^tm1.2Ipc
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim28^tm1.2Ipc mutation (0 available); any Trim28 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:62628 )

• die at E6.5-E8.5

embryo

abnormal endoderm development ( J:62628 )

• abnormal endoderm differentiation; reduced cell number

absent mesoderm ( J:62628 )

• failure of mesoderm formation

abnormal extraembryonic endoderm formation ( J:62628 )

• altered morphology

Allelic Composition	Trim28^chatwo/Trim28^tm1.2Ipc
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim28^chatwo mutation (0 available); any Trim28 mutation (35 available)
Trim28^tm1.2Ipc mutation (0 available); any Trim28 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:178936 )

• some embryos arrest at E7.5 while others survive until E8.5

embryo

embryonic growth arrest ( J:178936 )

• some embryos arrest at E7.5 while others survive until E8.5

Allelic Composition	Trim28^tm1.1Ipc/Trim28^tm1.2Ipc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (44 available)
Trim28^tm1.1Ipc mutation (1 available); any Trim28 mutation (35 available)
Trim28^tm1.2Ipc mutation (0 available); any Trim28 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:178936 )

N	• embryos no normal yolk sac protrusions or trophoblast malformations

abnormal vitelline vasculature morphology ( J:178936 )

short rostral-caudal axis ( J:178936 )

embryonic growth arrest ( J:178936 )

• at E8.5

abnormal lateral plate mesoderm morphology ( J:178936 )

• shorter and wider than in control mice

wavy neural tube ( J:178936 )

nervous system

wavy neural tube ( J:178936 )

digestive/alimentary system

abnormal digestive system development ( J:178936 )

• failure of gut closure

cardiovascular system

abnormal vitelline vasculature morphology ( J:178936 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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