Phenotypes associated with this allele

• Allele Symbol: Uncx^tm1Akis
• Allele Name: targeted mutation 1, Andreas Kispert
• Allele ID: MGI:1859373
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Uncx^tm1Akis/Uncx^tm1Akis	involves: 129P2/OlaHsd * NMRI	MGI:2174796

Genotype
MGI:2174796

hm1

• Allelic Composition: Uncx^tm1Akis/Uncx^tm1Akis
• Genetic Background: involves: 129P2/OlaHsd * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:62022 )

• die shortly after birth

skeleton

abnormal axial skeleton morphology ( J:62022 )

• severe malformations of the axial skeleton, however skull and appendicular skeleton appear normal

abnormal thoracic cage morphology ( J:62022 )

• rib cage is distorted

abnormal sternum morphology ( J:62022 )

• sternal malformations

asymmetric costovertebral joints ( J:62022 )

• rib joints are missing and proximal ends of ribs do not contact vertebral bodies but are weakly attached to the laminae or float freely

absent proximal rib ( J:62022 )

decreased rib number ( J:62022 )

• 13th rib is absent

rib fusion ( J:62022 )

• occasional fusion of ribs

lordosis ( J:62022 )

• shortened body axis due to severe lordosis in the thoracic region of the vertebral column

scoliosis ( J:62022 )

abnormal vertebrae morphology ( J:62022 )

absent vertebral pedicles ( J:62022 )

• strongly reduced or absent

absent vertebral transverse processes ( J:62022 )

abnormal vertebral body morphology ( J:62022 )

• observe split ossification centers of vertebral bodies and occasionally increased width of vertebral bodies

abnormal sclerotome morphology ( J:62022 )

• vertebral structures derived from the lateral sclerotomal mesenchyme are lost, suggesting that this mesenchyme is unable to proliferate and condense or form a cartilaginous preskeleton

nervous system

abnormal dorsal root ganglion morphology ( J:62022 )

• dorsal root ganglia are expanded, perturbed and fail to form distinct entities at E10.5

fused dorsal root ganglion ( J:62022 )

• fused along the entire vertebral column

respiratory system

respiratory failure ( J:62022 )

• thoracic cavity is smaller and lungs are hardly inflated, possibly indicating respiratory failure

renal/urinary system

renal/urinary system phenotype ( J:62022 )

N • no abnormal kidney phenotypes detected

growth/size/body

small thoracic cavity ( J:62022 )