All Phenotypes Pou3f1<tm1Rsd> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pou3f1^tm1Rsd
targeted mutation 1, Michael G Rosenfeld
MGI:1857994

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pou3f1^tm1Rsd/Pou3f1^tm1Rsd	either: (involves: 129S4/SvJae * 129/Sv * C57BL/6J) or (involves: 129S4/SvJae * C57BL/6 * C57BL/6J)	MGI:2655754
hm2	Pou3f1^tm1Rsd/Pou3f1^tm1Rsd	involves: 129/Sv * 129S4/SvJae * C57BL/6J	MGI:2665327
cx3	Pou2f3^tm1Rsd/Pou2f3^tm1Rsd Pou3f1^tm1Rsd/Pou3f1^tm1Rsd	involves: 129/Sv * 129S4/SvJae * C57BL/6J	MGI:2665472

Allelic Composition	Pou3f1^tm1Rsd/Pou3f1^tm1Rsd
Genetic Background	either: (involves: 129S4/SvJae * 129/Sv * C57BL/6J) or (involves: 129S4/SvJae * C57BL/6 * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou3f1^tm1Rsd mutation (0 available); any Pou3f1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:34460 )

• most mice die within 2 hours of birth; death attributed to respiratory failure

postnatal lethality, complete penetrance ( J:34460 )

• rare animals survive up to 22 days

homeostasis/metabolism

cyanosis ( J:34460 )

• pups were cyanotic at birth

respiratory system

respiratory failure ( J:34460 )

• death attributed to respiratory failure

nervous system

abnormal olfactory tract morphology ( J:34460 )

• the nucleus of the lateral olfactory tract is displaced in P0 brains and displaced, and diminished or missing in P4 brains

abnormal phrenic nerve morphology ( J:34460 )

• abnormalities in position and number of phrenic motoneurons

abnormal sciatic nerve morphology ( J:34460 )

• few axons in the sciatic nerve were myelinated

abnormal myelination ( J:34460 )

• most myelinating Schwann cells failed to mature beyond the ensheathment stage

integument

integument phenotype ( J:34460 )

N	• skin appeared grossly normal

Allelic Composition	Pou3f1^tm1Rsd/Pou3f1^tm1Rsd
Genetic Background	involves: 129/Sv * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou3f1^tm1Rsd mutation (0 available); any Pou3f1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34460 )

• rare animals survive up to 22 days

Allelic Composition	Pou2f3^tm1Rsd/Pou2f3^tm1Rsd Pou3f1^tm1Rsd/Pou3f1^tm1Rsd
Genetic Background	involves: 129/Sv * 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f3^tm1Rsd mutation (0 available); any Pou2f3 mutation (33 available)
Pou3f1^tm1Rsd mutation (0 available); any Pou3f1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:42016 )

• most mice die soon after birth

integument

integument phenotype ( J:42016 )

N	• no overt skin abnormalities in neonates

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23