Pou2f3^tm1Rsd
Targeted Allele Detail

Summary

• Symbol: Pou2f3^tm1Rsd
• Name: POU domain, class 2, transcription factor 3; targeted mutation 1, Michael G Rosenfeld
• MGI ID: MGI:2450109
• Synonyms: Skn-1a/i-
• Gene: Pou2f3 Location: Chr9:43035222-43117052 bp, - strand Genetic Position: Chr9, 24.21 cM
• Alliance: Pou2f3^tm1Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42016
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 5.0 kb of sequence encoding a part of the amino terminus, all of the POU-specific domain, and a large part of the POU homeodomain. RNase protection assay did not detect transcript in either adult or neonatal skin from homozygous mutant animals. (J:42016)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou2f3 Mutation: 36 strains or lines available

References

• Original: J:42016 Andersen B, et al., Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation. Genes Dev. 1997 Jul 15;11(14):1873-84
• All: 1 reference(s)