Phenotypes associated with this allele

• Allele Symbol: Grm1^tm1Stl
• Allele Name: targeted mutation 1, Susumu Tonegawa
• Allele ID: MGI:1857987
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm1^tm1Stl/Grm1^tm1Stl	involves: 129S2/SvPas * C57BL/6	MGI:2176847
cx2	Grm1^tm1Stl/Grm1^tm1Stl Pcp2^tm1(tTA)23Atai/Pcp2^+ Tg(tetO-Grm1)7Atai/?	involves: 129S2/SvPas * C57BL/6N	MGI:3715322

Genotype
MGI:2176847

hm1

• Allelic Composition: Grm1^tm1Stl/Grm1^tm1Stl
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced fertility ( J:21086 )

• males and females are fertile but poor breeders

nervous system

nervous system phenotype ( J:21086 )

N • no gross anatomical abnormalities are observed in the hippocampus, cerebellum, or olfactory bulb, in synaptic transmission at the CA1 Schaffer collateral synapses of the hippocampus or in primary hippocampal cultures, and in long-term depression (LTD)

abnormal excitatory postsynaptic currents ( J:73385 )

• increase in the incidence of climbing fiber induced excitatory postsynaptic currents with more than one discrete step in mutant Purkinje cells compared to wild-type cells

short excitatory postsynaptic current decay time ( J:73385 )

• decay constants are significantly shorter than those of wild-type currents

reduced long-term potentiation ( J:21086 )

• reduced hippocampal long-term potentiation (LTP)

behavior/neurological

abnormal contextual conditioning behavior ( J:21086 )

• moderate deficit in context-specific associative learning

tremors ( J:21086 )

• mice can sit still but upon initiation of movement they exhibit a whole-body tremor that persists throughout the duration of the movement

ataxia ( J:21086 )

• at 2 weeks, mice display mild ataxia

Genotype
MGI:3715322

cx2

• Allelic Composition: Grm1^tm1Stl/Grm1^tm1Stl; Pcp2^{tm1(tTA)23Atai}/Pcp2⁺; Tg(tetO-Grm1)7Atai/?
• Genetic Background: involves: 129S2/SvPas * C57BL/6N

behavior/neurological

behavior/neurological phenotype ( J:122536 )

N • ataxic gait seen in Grm1^tm1Stl homozygotes is rescued by the active transgene

abnormal behavior ( J:122536 )

abnormal motor coordination/balance ( J:122536 )

• following treatment with doxycycline begun at P24, mice fall off a rotating rod immediately and after several trials the average retention time is less than in wild-type mice at 41 days post treatment

abnormal gait ( J:122536 )

• following treatment with doxycycline begun at P24, mice have abnormal gaits and steps with different degrees of severity at 37 days post treatment