All Phenotypes Bmp8a<tm1Blh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bmp8a^tm1Blh
targeted mutation 1, Brigid L Hogan
MGI:1857953

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmp8a^tm1Blh/Bmp8a^tm1Blh	involves: 129S6/SvEvTac * Black Swiss	MGI:2450604
ht2	Bmp8a^tm1Blh/Bmp8a⁺	involves: 129S6/SvEvTac * Black Swiss	MGI:2450606
cx3	Bmp8a^tm1Blh/Bmp8a⁺ Bmp8b^tm1Blh/Bmp8b⁺	involves: 129/Sv * 129S6/SvEvTac * Black Swiss	MGI:2450605
cx4	Bmp7^tm1Rob/Bmp7⁺ Bmp8a^tm1Blh/Bmp8a^tm1Blh	involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss	MGI:2451055
cx5	Bmp7^tm1Rob/Bmp7⁺ Bmp8a^tm1Blh/Bmp8a^tm1Blh	involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6	MGI:2451053

Allelic Composition	Bmp8a^tm1Blh/Bmp8a^tm1Blh
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8a^tm1Blh mutation (0 available); any Bmp8a mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

increased male germ cell apoptosis ( J:46927 )

• 47% of 12 to 30 wk old mutant mice exhibit varying degrees of germ cell degeneration in 1% to 50% of seminiferous tubules

• degeneration is predominantly through apoptosis

• increase in number of apoptotic pachytene spermatocytes

seminiferous tubule degeneration ( J:46927 )

abnormal spermatogenesis ( J:46927 )

• present but abnormal

abnormal spermiogenesis ( J:46927 )

• compromised or absent spermiogenesis in many seminiferous tubules

abnormal epididymis morphology ( J:46927 )

• granulomatous inflammation is sometimes noted in the epididymal tubules of breeding male mice

epididymis epithelium degeneration ( J:46927 )

reduced male fertility ( J:46927 )

• male mice are initially fertile, however, 2 of 16 mice become infertile with age; females are fertile

immune system

granulomatous inflammation ( J:46927 )

• sometimes noted in the epididymal tubules of breeding male mice

endocrine/exocrine glands

seminiferous tubule degeneration ( J:46927 )

cellular

increased male germ cell apoptosis ( J:46927 )

• 47% of 12 to 30 wk old mutant mice exhibit varying degrees of germ cell degeneration in 1% to 50% of seminiferous tubules

• degeneration is predominantly through apoptosis

• increase in number of apoptotic pachytene spermatocytes

Allelic Composition	Bmp8a^tm1Blh/Bmp8a⁺
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8a^tm1Blh mutation (0 available); any Bmp8a mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male germ cell morphology ( J:46927 )

• about 17% of male mice examined exhibited abnormalities similar to homozygous mutant mice

abnormal spermatogenesis ( J:46927 )

• about 17% of male mice examined exhibited abnormalities similar to homozygous mutant mice

cellular

abnormal male germ cell morphology ( J:46927 )

• about 17% of male mice examined exhibited abnormalities similar to homozygous mutant mice

Allelic Composition	Bmp8a^tm1Blh/Bmp8a⁺ Bmp8b^tm1Blh/Bmp8b⁺
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8a^tm1Blh mutation (0 available); any Bmp8a mutation (19 available)
Bmp8b^tm1Blh mutation (1 available); any Bmp8b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male germ cell morphology ( J:46927 )

• about half of male mice examined exhibited abnormalities similar to homozygous Bmp8a^tm1Blh mice

abnormal spermatogenesis ( J:46927 )

• about 50% of male mice examined exhibited abnormalities similar to Bmp8a^tm1Blh/ Bmp8a^tm1Blh mice

epididymis epithelium degeneration ( J:46927 )

• is sometimes observed

immune system

granulomatous inflammation ( J:46927 )

• is sometimes noted in the epididymal tubules of breeding male mice

cellular

abnormal male germ cell morphology ( J:46927 )

• about half of male mice examined exhibited abnormalities similar to homozygous Bmp8a^tm1Blh mice

Allelic Composition	Bmp7^tm1Rob/Bmp7⁺ Bmp8a^tm1Blh/Bmp8a^tm1Blh
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp7^tm1Rob mutation (2 available); any Bmp7 mutation (37 available)
Bmp8a^tm1Blh mutation (0 available); any Bmp8a mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased testis weight ( J:78867 )

• average testes weights were comparable at 2 and 4 weeks of age and reduced at 6 and 13 weeks of age relative to age matched Bmp8a^tm1Blh homozygous mutant

reproductive system

decreased testis weight ( J:78867 )

• average testes weights were comparable at 2 and 4 weeks of age and reduced at 6 and 13 weeks of age relative to age matched Bmp8a^tm1Blh homozygous mutant

abnormal epididymis morphology ( J:78867 )

• similar epididymal phenotype as Bmp8a^tm1Blh homozygous mutant mice

Allelic Composition	Bmp7^tm1Rob/Bmp7⁺ Bmp8a^tm1Blh/Bmp8a^tm1Blh
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

granulomatous inflammation ( J:78867 )

• granuloma formation more pronounced than in Bmp8a^tm1Blh homozygous mutant mice

reproductive system

abnormal male germ cell morphology ( J:78867 )

• higher incidence of germ cell degeneration than in homozygous mutant mice, observed in 40 to 80% of examined seminiferous tubules

abnormal spermatogenesis ( J:78867 )

abnormal epididymis morphology ( J:78867 )

• blockage and accumulation of sperm

epididymis degeneration ( J:78867 )

• 67% exhibited severe epididymal degeneration

epididymis epithelium degeneration ( J:78867 )

male infertility ( J:78867 )

• 75% of male mice were infertile

cellular

abnormal male germ cell morphology ( J:78867 )

• higher incidence of germ cell degeneration than in homozygous mutant mice, observed in 40 to 80% of examined seminiferous tubules

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