Phenotypes associated with this allele

• Allele Symbol: Bmp1^tm1Blh
• Allele Name: targeted mutation 1, Brigid L Hogan
• Allele ID: MGI:1857952
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmp1^tm1Blh/Bmp1^tm1Blh	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:2175727
cx2	Bmp1^tm1Blh/Bmp1^tm1Blh Tll1^tm1Dgr/Tll1^tm1Dgr	involves: 129 * Black Swiss	MGI:2667447

Genotype
MGI:2175727

hm1

• Allelic Composition: Bmp1^tm1Blh/Bmp1^tm1Blh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:36830 )

• a small number of E17.5 embryos are dead or severely growth retarded

• most pups are believed to die at birth

• only one pup was noted to survive more than a day after birth

craniofacial

small frontal bone ( J:36830 )

• reduced in size

small interparietal bone ( J:36830 )

• reduced in size

small parietal bone ( J:36830 )

• reduced in size

embryo

embryo phenotype ( J:36830 )

N • normal dorsal-ventral patterning of the neural tube

N • normal limb development

abnormal embryonic tissue morphology ( J:36830 )

• mesodermal cells of the ventral body wall do not attach to the umbilical vessels efficiently

abnormal amnion morphology ( J:36830 )

• amnion is intact but the part of the membrane normally covering the herniated gut is absent

skeleton

skeleton phenotype ( J:36830 )

N • normal skull length

N • normal skeletalgenesis, except for membrane bones of the skull

small frontal bone ( J:36830 )

• reduced in size

small interparietal bone ( J:36830 )

• reduced in size

small parietal bone ( J:36830 )

• reduced in size

growth/size/body

herniated abdominal wall ( J:36830 )

• almost all E17.5 embryos have herniated guts

• the one pup to survive more than a day after birth had severe abdominal bleeding

digestive/alimentary system

abnormal intestine morphology ( J:36830 )

• a membrane consisting of endoderm and mesoderm material normally found surrounding the gut of E17.5 embryos is absent in these mice

Genotype
MGI:2667447

cx2

• Allelic Composition: Bmp1^tm1Blh/Bmp1^tm1Blh; Tll1^tm1Dgr/Tll1^tm1Dgr
• Genetic Background: involves: 129 * Black Swiss

mortality/aging

prenatal lethality, complete penetrance ( J:83994 )

• mice do not survive until birth

cardiovascular system

abnormal aorta morphology ( J:83994 )

• mispositioning of the aorta to the center

abnormal heart position or orientation ( J:83994 )

• mispositioning of the entire heart to the left

• no observed defects of the outflow tract septum

muscular ventricular septal defect ( J:83994 )

• large defects in the muscular interventricular septum are observed in E13.5 embryos

congestive heart failure ( J:83994 )

• is noted in E13.5 embryos and is accompanied by edema