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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pax9+
wild type
MGI:1857888
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Pax9tm1.2(Osr2)Jian/Pax9+ involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/N MGI:5013436
cx2
 		Msx1tm1Rilm/Msx1+
Pax9tm1Rbal/Pax9+ 		involves: 129 * CD-1 MGI:7294560
cx3
 		Msx1tm1Rilm/Msx1tm1Rilm
Pax9tm1Rbal/Pax9+ 		involves: 129 * CD-1 MGI:7294561
cx4
 		Osr2tm1Jian/Osr2tm1Jian
Pax9tm1.2(Osr2)Jian/Pax9+ 		involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/N MGI:5013437
cx5
 		Osr2tm1Jian/Osr2tm1Jian
Pax9tm1.1(Osr2)Jian/Pax9+ 		involves: 129S1/Sv * C57BL/6J * FVB/N MGI:5013438


Genotype
MGI:5013436
ht1
Allelic
Composition		 Pax9tm1.2(Osr2)Jian/Pax9+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax9tm1.2(Osr2)Jian mutation (0 available); any Pax9 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:173121 )
N
• mice exhibit normal tooth development




Genotype
MGI:7294560
cx2
Allelic
Composition		 Msx1tm1Rilm/Msx1+
Pax9tm1Rbal/Pax9+
Genetic
Background		 involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Rilm mutation (1 available); any Msx1 mutation (18 available)
Pax9tm1Rbal mutation (0 available); any Pax9 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
decreased tooth number ( J:311535 )
• absence of lower teeth

growth/size/body
decreased tooth number ( J:311535 )
• absence of lower teeth

skeleton
decreased tooth number ( J:311535 )
• absence of lower teeth




Genotype
MGI:7294561
cx3
Allelic
Composition		 Msx1tm1Rilm/Msx1tm1Rilm
Pax9tm1Rbal/Pax9+
Genetic
Background		 involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Rilm mutation (1 available); any Msx1 mutation (18 available)
Pax9tm1Rbal mutation (0 available); any Pax9 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial

digestive/alimentary system

growth/size/body
cleft palate ( J:311535 )




Genotype
MGI:5013437
cx4
Allelic
Composition		 Osr2tm1Jian/Osr2tm1Jian
Pax9tm1.2(Osr2)Jian/Pax9+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Osr2tm1Jian mutation (1 available); any Osr2 mutation (18 available)
Pax9tm1.2(Osr2)Jian mutation (0 available); any Pax9 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:173121 )
N
• mice exhibit a normal number of teeth
cleft secondary palate ( J:173121 )
• in some mice

digestive/alimentary system
cleft secondary palate ( J:173121 )
• in some mice

growth/size/body
cleft secondary palate ( J:173121 )
• in some mice




Genotype
MGI:5013438
cx5
Allelic
Composition		 Osr2tm1Jian/Osr2tm1Jian
Pax9tm1.1(Osr2)Jian/Pax9+
Genetic
Background		 involves: 129S1/Sv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Osr2tm1Jian mutation (1 available); any Osr2 mutation (18 available)
Pax9tm1.1(Osr2)Jian mutation (0 available); any Pax9 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal tooth development ( J:173121 )
• mice exhibit supernumerary tooth germs lingual to the maxillary molar compared with wild-type mice
• at E15.5 and E16.5, the oral epithelium lingual to the mandibular first molar tooth germs is thickened compared to in control mice
• however, the number of teeth in the mandible is normal
cleft secondary palate ( J:173121 )
• in all mice

digestive/alimentary system
cleft secondary palate ( J:173121 )
• in all mice

growth/size/body
abnormal tooth development ( J:173121 )
• mice exhibit supernumerary tooth germs lingual to the maxillary molar compared with wild-type mice
• at E15.5 and E16.5, the oral epithelium lingual to the mandibular first molar tooth germs is thickened compared to in control mice
• however, the number of teeth in the mandible is normal
cleft secondary palate ( J:173121 )
• in all mice

skeleton
abnormal tooth development ( J:173121 )
• mice exhibit supernumerary tooth germs lingual to the maxillary molar compared with wild-type mice
• at E15.5 and E16.5, the oral epithelium lingual to the mandibular first molar tooth germs is thickened compared to in control mice
• however, the number of teeth in the mandible is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory