Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hoxb1tm3Mrc targeted mutation 3, Mario R Capecchi MGI:1857859 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• authors state that mice exhibit the same phenotype as other null alleles of Hoxb1tm2Mrc homozygotes
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• authors state that mice exhibit the same phenotype as other null alleles of Hoxb1tm2Mrc homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• apoptosis in the hindbrain is increased and extends more posteriorly than in Hoxa1 null mice
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• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice
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• hindbrain organization into even- and odd-numbered rhombomeres is lacking
• molecular markers reveal a lack of rhombomeres 4 and 5
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• mice lack the orbicularis occuli muscle
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• hindbrain organization into even- and odd-numbered rhombomeres is lacking
• molecular markers reveal a lack of rhombomeres 4 and 5
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• the second branchial pouch is absent
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• the shape of the third pharyngeal pouch is distorted
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• the incus is reduced in size
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• the stapes derived from the second branchial arch is absent
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• mice lack the orbicularis occuli muscle
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• mice lack the levator labii maxillaris, orbicularis occuli and zygomatic muscles
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• mice lack the levator labii maxillaris
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• mice lack the zygomatic muscles
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• the incus is reduced in size
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• the stapes derived from the second branchial arch is absent
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• the posterior belly of the digastric and stylohyoid muscles form but act as a single muscle
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• the posterior belly of the digastric and stylohyoid muscles form but act as a single muscle
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• at birth, mice exhibit lung hypoplasia that ranges from 5 small lobes to the presence of only two lobes
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• mice lack the orbicularis occuli muscle
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• mice lack the levator labii maxillaris, orbicularis occuli and zygomatic muscles
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• mice lack the levator labii maxillaris
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• mice lack the zygomatic muscles
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• the posterior belly of the digastric and stylohyoid muscles form but act as a single muscle
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• the posterior belly of the digastric and stylohyoid muscles form but act as a single muscle
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• the incus is reduced in size
|
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• the stapes derived from the second branchial arch is absent
|
|
• apoptosis in the hindbrain is increased and extends more posteriorly than in Hoxa1 null mice
|
|
• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice
|
|
• mice lack the orbicularis occuli muscle
|
|
• mice lack the levator labii maxillaris, orbicularis occuli and zygomatic muscles
|
|
• mice lack the levator labii maxillaris
|
|
• mice lack the zygomatic muscles
|
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice
|
|
• hindbrain organization into even- and odd-numbered rhombomeres is lacking
|
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• hindbrain organization into even- and odd-numbered rhombomeres is lacking
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• some mice exhibit a distortion of the second and third pouch towards the first
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• branchiomotor neurons do not fasciculate and exit at multiple points along the neural tube unlike in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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