Phenotypes associated with this allele

• Allele Symbol: Fbxw4^Dac-2J
• Allele Name: dactylaplasia 2 Jackson
• Allele ID: MGI:1857834
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxw4^Dac-2J/Fbxw4^Dac-2J	CBy.MRL-Fbxw4^Dac-2J/J	MGI:3027954
cx2	Fbxw4^Dac-2J/Fbxw4^Dac-2J mdac/mdac	CBy.MRL-Fbxw4^Dac-2J/J	MGI:2175878
cx3	Fbxw4^Dac-2J/Fbxw4^+ mdac/mdac	CBy.MRL-Fbxw4^Dac-2J/J	MGI:4456999

Genotype
MGI:3027954

hm1

• Allelic Composition: Fbxw4^Dac-2J/Fbxw4^Dac-2J
• Genetic Background: CBy.MRL-Fbxw4^Dac-2J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

oligodactyly ( J:57316 )

• mice were viable and fertile but had more severe digit malformations; only a single remaining digit

Genotype
MGI:2175878

cx2

• Allelic Composition: Fbxw4^Dac-2J/Fbxw4^Dac-2J; mdac/mdac
• Genetic Background: CBy.MRL-Fbxw4^Dac-2J/J

mortality/aging

prenatal lethality, complete penetrance ( J:57316 )

• gestation day not specified

Genotype
MGI:4456999

cx3

• Allelic Composition: Fbxw4^Dac-2J/Fbxw4⁺; mdac/mdac
• Genetic Background: CBy.MRL-Fbxw4^Dac-2J/J

limbs/digits/tail

ectrodactyly ( J:57316 )

• affects particularly the three middle digits, on each foot

• often the metatarsal and metacarpal bones are partially or completely missing or fused; the forefeet are more severely affected than the hindfeet

• the defects are clearly recognizable in 15-day embryos

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
split hand-foot malformation 3		DOID:0090025	OMIM:246560	J:133888