Phenotypes associated with this allele

• Allele Symbol: nt
• Allele Name: no turning
• Allele ID: MGI:1857804
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	nt/nt	CD-1	MGI:2169805

Genotype
MGI:2169805

hm1

• Allelic Composition: nt/nt
• Genetic Background: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:45709 )

• homozygous embryos die at E9.5-E11.5

cardiovascular system

abnormal direction of heart looping ( J:45709 )

• homozygotes exhibit randomized left-right heart looping

pericardial effusion ( J:45709 )

• a ballooning of the pericardial sac and blood accumulations were found at various stages

embryo

small pharyngeal arch ( J:45709 )

• the branchial arches appear reduced in size

incomplete embryo turning ( J:45709 )

• axial rotation was not completed or in some cases was not initiated

decreased embryo size ( J:45709 )

• at E9.5, homozygous embryos are 50% smaller than littermates and remain smaller until death

absent floor plate ( J:45709 )

• the floorplate was undetectable at E10.5, although it was seen at E8.5

delayed neural tube closure ( J:45709 )

• closure is not initiated in embryos with 10-12 somites; the elevation of the neural folds is delayed and the rostral neural plate appears flattened

open neural tube ( J:45709 )

• some embryos exhibit a failure to fuse the neural folds along the midbrain/hindbrain region

notochord degeneration ( J:45709 )

• a progressive degeneration of the notochord was noted

abnormal somite shape ( J:45709 )

decreased somite size ( J:45709 )

• somites appear smaller than normal

incomplete somite formation ( J:45709 )

• only a maximum of 20 somite pairs form

abnormal tail bud morphology ( J:45709 )

• variable penetrance; in the most severely affected embryos, the tail bud was small and undifferentiated

small tail bud ( J:45709 )

• in severely affected embryos

abnormal chorioallantoic fusion ( J:45709 )

• the allantois detaches from the embryonic membranes during dissection

growth/size/body

decreased embryo size ( J:45709 )

• at E9.5, homozygous embryos are 50% smaller than littermates and remain smaller until death

nervous system

absent floor plate ( J:45709 )

• the floorplate was undetectable at E10.5, although it was seen at E8.5

delayed neural tube closure ( J:45709 )

• closure is not initiated in embryos with 10-12 somites; the elevation of the neural folds is delayed and the rostral neural plate appears flattened

open neural tube ( J:45709 )

• some embryos exhibit a failure to fuse the neural folds along the midbrain/hindbrain region

abnormal brain ventricle morphology ( J:45709 )

• the shape of the ventricles is abnormal due to an expansion of the rostral cranial cavities

craniofacial

small frontonasal prominence ( J:45709 )

• the frontonasal process appears reduced in size

small pharyngeal arch ( J:45709 )

• the branchial arches appear reduced in size

limbs/digits/tail

abnormal tail bud morphology ( J:45709 )

• variable penetrance; in the most severely affected embryos, the tail bud was small and undifferentiated

small tail bud ( J:45709 )

• in severely affected embryos

homeostasis/metabolism

pericardial effusion ( J:45709 )

• a ballooning of the pericardial sac and blood accumulations were found at various stages