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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srydl1Rlb
sex determining region of Chr Y-deletion 1, Robin Lovell-Badge
MGI:1857786
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		X/Srydl1Rlb
Tg(Sry)2Ei/0 		involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1 MGI:3043703
cx2
 		X/Del(Y)1PsbSrydl1Rlb
Tg(Sry)2Ei/0 		involves: 129S6/SvEvTac * MF1 MGI:3043585
ot3
 		X/Srydl1Rlb involves: 129S6/SvEvTac * C57BL/6JEi * MF1 MGI:3041950


Genotype
MGI:3043703
cx1
Allelic
Composition		 X/Srydl1Rlb
Tg(Sry)2Ei/0
Genetic
Background		 involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srydl1Rlb mutation (2 available); any Sry mutation (54 available)
Tg(Sry)2Ei mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
primary sex reversal ( J:89312 )
• chromosomal males that would have developed as fertile females develop as males




Genotype
MGI:3043585
cx2
Allelic
Composition		 X/Del(Y)1PsbSrydl1Rlb
Tg(Sry)2Ei/0
Genetic
Background		 involves: 129S6/SvEvTac * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(Y)1Psb mutation (0 available); any Del(Y)1Psb mutation (0 available)
Srydl1Rlb mutation (2 available); any Sry mutation (54 available)
Tg(Sry)2Ei mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal acrosome morphology ( J:89616 )
• all sperm exhibit defects in acrosomal morphology

cellular
abnormal acrosome morphology ( J:89616 )
• all sperm exhibit defects in acrosomal morphology




Genotype
MGI:3041950
ot3
Allelic
Composition		 X/Srydl1Rlb
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6JEi * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srydl1Rlb mutation (2 available); any Sry mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
primary sex reversal ( J:46791 )
• chromosomal XY males carrying this allele develop as fertile females




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory