Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntftm1Mpin mutation
(1 available);
any
Cntf mutation
(13 available)
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nervous system
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• in MOG33-35-treated mice
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• increased in MOG33-35-treated mice
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• severe vascular dystrophy of myelin in MOG33-35-treated mice
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• in MOG33-35-treated mice
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immune system
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• mice treated with MOG33-35 exhibit more severe experimental autoimmune encephalomyelitis with decreased oligodendrocyte precursor cells, increased oligodendrocyte apoptosis, and severe vacuolar dystrophy of myelin and axonal damage compared with wild-type mice
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cellular
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• in MOG33-35-treated mice
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• increased in MOG33-35-treated mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntftm1Mpin mutation
(1 available);
any
Cntf mutation
(13 available)
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nervous system
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• atrophic and degenerative changes in spinal motor neurons are accompanied by an increase in the numbers of activated microglial cells
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• at 8 weeks of age, lumbar motor neuron cell bodies are smaller and the nuclei are swollen, resulting in an increase in the ratio between nuclear and cytoplasmic areas of about 40%, however by 14 weeks of age, both cell area and nuclear area are smaller
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• 22% reduction in facial motor neurons at 28 weeks of age but not at 4 weeks of age
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• with increasing age, spinal motor neurons exhibit progressive atrophy and finally degeneration
• trophy becomes apparent by 8 weeks of age and the first signs of degeneration are seen at 22 weeks of age
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muscle
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• small but significant reduction in muscle strength at 28 weeks of age, as indicated by forelimb grip strength
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behavior/neurological
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• small but significant reduction in forelimb grip strength at 28 weeks of age
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hematopoietic system
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• atrophic and degenerative changes in spinal motor neurons are accompanied by an increase in the numbers of activated microglial cells
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immune system
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• atrophic and degenerative changes in spinal motor neurons are accompanied by an increase in the numbers of activated microglial cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntftm1Mpin mutation
(1 available);
any
Cntf mutation
(13 available)
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homeostasis/metabolism
nervous system
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• mice exhibit extensive terminal sprouting in response to major sprouting-stimuli (CNTF, botulinum toxin-elicited paralysis, and partial denervation by L4 spinal root transection) with normal numbers, length, and growth patterns of terminal sprouts, and extent of reinnervation by terminal or nodal sprouts
• mice exhibit normal induction of nerve terminal sprouting, reactivation of terminal Schwann cells, and compensatory reinnervation after nerve injury
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• after optic nerve crush and or lens injury, axotomized retinal ganglion cells exhibit reduced neurite outgrowth compared with wild-type cells
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• stronger activation following optic nerve crush injury
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cellular
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• after optic nerve crush and or lens injury, axotomized retinal ganglion cells exhibit reduced neurite outgrowth compared with wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntftm1Mpin mutation
(1 available);
any
Cntf mutation
(13 available)
Liftm1Phb mutation
(0 available);
any
Lif mutation
(11 available)
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nervous system
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• after optic nerve crush and lens injury, axotomized retinal ganglion cells fail to exhibit neurite outgrowth unlike with wild-type cells
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homeostasis/metabolism
cellular
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• after optic nerve crush and lens injury, axotomized retinal ganglion cells fail to exhibit neurite outgrowth unlike with wild-type cells
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Analysis Tools