All Phenotypes Ikbkb<tm1Mka> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ikbkb^tm1Mka
targeted mutation 1, Michael Karin
MGI:1857769

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ikbkb^tm1Mka/Ikbkb^tm1Mka	involves: 129S6/SvEvTac * C57BL/6	MGI:2179398

Allelic Composition	Ikbkb^tm1Mka/Ikbkb^tm1Mka
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkb^tm1Mka mutation (0 available); any Ikbkb mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Anemic appearance of E13.5 Ikbkb^tm1Mka/Ikbkb^tm1Mka mutants

mortality/aging

• dead by E13.5

liver/biliary system

abnormal hepatocyte morphology ( J:55737 )

• no viable hepatocytes were detected at E13.5 and the numbers of dead cells with highly condensed and fragmented nuclei were markedly increased

liver degeneration ( J:55737 )

• degeneration of the liver is seen at E13.5, however limbs and head developed normally

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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