All Phenotypes Gsc<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gsc⁺
wild type
MGI:1857727

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dkk1^tm1Lmgd/Dkk1⁺ Gsc^tm2Bhr/Gsc⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3716765
cx2	Foxa2^tm1Jrt/Foxa2^tm1Jrt Gsc^tm1Bhr/Gsc⁺	involves: 129/Sv * C57BL/6 * CD-1	MGI:3716761

Allelic Composition	Dkk1^tm1Lmgd/Dkk1⁺ Gsc^tm2Bhr/Gsc⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1^tm1Lmgd mutation (0 available); any Dkk1 mutation (17 available)
Gsc^tm2Bhr mutation (1 available); any Gsc mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased forebrain size ( J:119933 )

• about 43% of embryos at E7.5 - E9.5 display a mild reduction in forebrain size

Allelic Composition	Foxa2^tm1Jrt/Foxa2^tm1Jrt Gsc^tm1Bhr/Gsc⁺
Genetic Background	involves: 129/Sv * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa2^tm1Jrt mutation (2 available); any Foxa2 mutation (28 available)
Gsc^tm1Bhr mutation (0 available); any Gsc mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:41809 )

• phenotype at E9.5 is similar to that of Foxa2 single homozygotes with no increase in the severity of the defect in development of the anterior posterior axis

decreased embryo size ( J:41809 )

• embryos are small and thin

growth/size/body

decreased embryo size ( J:41809 )

• embryos are small and thin

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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