All Phenotypes Hif1a<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hif1a⁺
wild type
MGI:1857721

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hif1a^tm1Rsjo/Hif1a⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:4418485
ht2	Hif1a^tm1.1Mcs/Hif1a⁺	involves: 129S6/SvEvTac	MGI:3618335
cx3	Egln1^tm1.1Fsl/Egln1⁺ Hif1a^tm3.1Rsjo/Hif1a⁺	B6.Cg-Egln1^tm1.1Fsl Hif1a^tm3.1Rsjo	MGI:5525151
cx4	Egln2^tm1Pec/Egln2^tm1Pec Hif1a^tm1Pec/Hif1a⁺	involves: 129S/SvEv * Swiss	MGI:3777337
cx5	Egln3^tm1Pjr/Egln3^tm1Pjr Hif1a^tm1Pec/Hif1a⁺	involves: 129S/SvEv * Swiss	MGI:3798395

Allelic Composition	Hif1a^tm1Rsjo/Hif1a⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1a^tm1Rsjo mutation (0 available); any Hif1a mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased neuron apoptosis ( J:98637 )

• under hypoxic conditions compared with similarly treated wild-type mice

cellular

decreased neuron apoptosis ( J:98637 )

• under hypoxic conditions compared with similarly treated wild-type mice

Allelic Composition	Hif1a^tm1.1Mcs/Hif1a⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1a^tm1.1Mcs mutation (0 available); any Hif1a mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:105812 )

• although the majority of observed phenotypes do not result in lethality, some embryos do die (stage not specified)

embryo

abnormal embryo development ( J:105812 )

• between E10.5 and E13.5, about 50% of heterozygotes exhibit various developmental defects

cardiovascular system

pericardial effusion ( J:105812 )

• some embryos exhibit cardiac effusion

hemorrhage ( J:105812 )

• some E13.5 embryos exhibit minor hemorrhaging in the embryo and yolk sac

homeostasis/metabolism

pericardial effusion ( J:105812 )

• some embryos exhibit cardiac effusion

Allelic Composition	Egln1^tm1.1Fsl/Egln1⁺ Hif1a^tm3.1Rsjo/Hif1a⁺
Genetic Background	B6.Cg-Egln1^tm1.1Fsl Hif1a^tm3.1Rsjo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1^tm1.1Fsl mutation (1 available); any Egln1 mutation (23 available)
Hif1a^tm3.1Rsjo mutation (0 available); any Hif1a mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased hematocrit ( J:202737 )

Allelic Composition	Egln2^tm1Pec/Egln2^tm1Pec Hif1a^tm1Pec/Hif1a⁺
Genetic Background	involves: 129S/SvEv * Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln2^tm1Pec mutation (0 available); any Egln2 mutation (19 available)
Hif1a^tm1Pec mutation (0 available); any Hif1a mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:132630 )

N	• double mutants show ischemic muscle damage that is intermediate to Egln2/Epas1 double mutants and Egln2-null mice, so protection is partially lost in these animals

Allelic Composition	Egln3^tm1Pjr/Egln3^tm1Pjr Hif1a^tm1Pec/Hif1a⁺
Genetic Background	involves: 129S/SvEv * Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln3^tm1Pjr mutation (0 available); any Egln3 mutation (26 available)
Hif1a^tm1Pec mutation (0 available); any Hif1a mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal superior cervical ganglion morphology ( J:136034 )

• the number of neurons is similar to that in mice homozygous for Egln3^tm1Pjr alone

abnormal neuron physiology ( J:136034 )

• the nerve growth factor dose-response survival curve of superior cervical ganglia neurons is not significantly different from that of neurons homozygous for Egln3^tm1Pjr alone

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