Phenotypes associated with this allele

• Allele Symbol: Acvr1^tm1Enl
• Allele Name: targeted mutation 1, En Li
• Allele ID: MGI:1857711
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acvr1^tm1Enl/Acvr1^tm1Enl	involves: 129S4/SvJae * BALB/c	MGI:2183233

Genotype
MGI:2183233

hm1

• Allelic Composition: Acvr1^tm1Enl/Acvr1^tm1Enl
• Genetic Background: involves: 129S4/SvJae * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:54394 )

• all embryos dead by E9.5

• embryos abnormal by E7.5

embryo

abnormal embryo development ( J:54394 )

abnormal gastrulation ( J:54394 )

abnormal ectoderm development ( J:54394 )

• failure to form organized epithelial layer

decreased embryo size ( J:54394 )

• embryos significantly smaller than littermates, evident beginning at E7.5

thick embryonic epiblast ( J:54394 )

• epiblast was thickened, not forming its usual columnar shape

absent mesoderm ( J:54394 )

abnormal primitive streak formation ( J:54394 )

• absence of organized primitive streak

absent allantois ( J:54394 )

absent amnion ( J:54394 )

absent amniotic folds ( J:54394 )

absent chorion ( J:54394 )

abnormal visceral endoderm morphology ( J:54394 )

• abnormal visceral endoderm

growth/size/body

decreased embryo size ( J:54394 )

• embryos significantly smaller than littermates, evident beginning at E7.5