All Phenotypes Mafb<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mafb⁺
wild type
MGI:1857681

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mafb^em1Hts/Mafb⁺	involves: C57BL/6J	MGI:6471918
cx2	Mafb^tm1.2Good/Mafb⁺ Tg(Isl1-EGFP*)1Slp/0	involves: 129S4/SvJae * BALB/c * C57BL/6	MGI:6278262
cx3	Arhgap29^tm1Murr/Arhgap29⁺ Mafb^tm1.2Mardu/Mafb⁺	involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA	MGI:7256936

Allelic Composition	Mafb^em1Hts/Mafb⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafb^em1Hts mutation (0 available); any Mafb mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:296168 )

• mice do not show any gross abnormalities, including no renal problems, up to 2 months of age

Allelic Composition	Mafb^tm1.2Good/Mafb⁺ Tg(Isl1-EGFP*)1Slp/0
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafb^tm1.2Good mutation (0 available); any Mafb mutation (20 available)
Tg(Isl1-EGFP*)1Slp mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal innervation pattern to muscle ( J:237642 )

• by E12.5, aberrant branches of the oculomotor nerve begin to form in the direction of the lateral rectus muscle and retractor bulbi muscle

• at E13.5, the oculomotor nerve forms a second, more distal aberrant branch that extends toward the lateral rectus muscle in addition to the more proximal aberrant branches contacting the lateral rectus and retractor bulbi muscles

• by E16.5, the abducens nerve remains hypoplastic but provides some innervation to the lateral rectus muscle

• by E16.5, the lateral rectus muscle receives innervation form the distinct proximal and distal aberrant oculomotor nerve branches

• the diameter of the distal aberrant branch of the oculomotor nerve is greater than that of the proximal aberrant branch

abnormal abducens nerve morphology ( J:237642 )

• E11.5 embryos show hypoplastic abducens nerves

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duane retraction syndrome		DOID:12557	OMIM:126800	J:237642

Allelic Composition	Arhgap29^tm1Murr/Arhgap29⁺ Mafb^tm1.2Mardu/Mafb⁺
Genetic Background	involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap29^tm1Murr mutation (0 available); any Arhgap29 mutation (47 available)
Mafb^tm1.2Mardu mutation (0 available); any Mafb mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:311539 )

N	• mice born at normal Mendelian ratios

skeleton

skeleton phenotype ( J:311539 )

N	• normal palatogenesis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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