All Phenotypes Wnt5a<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wnt5a⁺
wild type
MGI:1857616

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Daam1^tm1.1Tpy/Daam1^tm1.1Tpy Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Wnt5a^tm1Amc/Wnt5a⁺	involves: 129S1/Sv * 129S7/SvEvBrd	MGI:6151066
cx2	Fzd2^tm1.1Nat/Fzd2⁺ Fzd7^tm1.1Nat/Fzd7^tm1.1Nat Wnt5a^tm1Amc/Wnt5a⁺	involves: 129 * C57BL/6	MGI:5444718
cx3	Fzd7^tm1.1Nat/Fzd7^tm1.1Nat Wnt5a^tm1Amc/Wnt5a⁺	involves: 129 * C57BL/6	MGI:5444717
cx4	Wnt4^tm1Amc/Wnt4^tm1Amc Wnt5a^tm1Amc/Wnt5a⁺ Wnt5b^tm1Tmj/Wnt5b^tm1Tmj	involves: 129S1/Sv * 129S7/SvEvBrd	MGI:4412399
cx5	Wnt4^tm1Amc/Wnt4^tm1Amc Wnt5a^tm1Amc/Wnt5a⁺	involves: 129S1/Sv * 129S7/SvEvBrd	MGI:4412393

Allelic Composition	Daam1^tm1.1Tpy/Daam1^tm1.1Tpy Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Wnt5a^tm1Amc/Wnt5a⁺
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Daam1^tm1.1Tpy mutation (0 available); any Daam1 mutation (76 available)
Nkx2-5^tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
Wnt5a^tm1Amc mutation (1 available); any Wnt5a mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardial trabeculae morphology ( J:228507 )

• thicker right ventricular trabecular zones, extending into lumen in E16.5 embryos

thick myocardium compact layer ( J:228507 )

• in right ventricle of E16.5 embryos

muscle

abnormal myocardial trabeculae morphology ( J:228507 )

• thicker right ventricular trabecular zones, extending into lumen in E16.5 embryos

thick myocardium compact layer ( J:228507 )

• in right ventricle of E16.5 embryos

Allelic Composition	Fzd2^tm1.1Nat/Fzd2⁺ Fzd7^tm1.1Nat/Fzd7^tm1.1Nat Wnt5a^tm1Amc/Wnt5a⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2^tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7^tm1.1Nat mutation (1 available); any Fzd7 mutation (38 available)
Wnt5a^tm1Amc mutation (1 available); any Wnt5a mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:189062 )

• all die by E11

growth/size/body

embryonic growth retardation ( J:189062 )

• starting at E9.5

embryo

embryonic growth retardation ( J:189062 )

• starting at E9.5

Allelic Composition	Fzd7^tm1.1Nat/Fzd7^tm1.1Nat Wnt5a^tm1Amc/Wnt5a⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd7^tm1.1Nat mutation (1 available); any Fzd7 mutation (38 available)
Wnt5a^tm1Amc mutation (1 available); any Wnt5a mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

short tail ( J:189062 )

• truncation is more severe than in mice homozygous for Fzd7^tm1.1Nat alone

Allelic Composition	Wnt4^tm1Amc/Wnt4^tm1Amc Wnt5a^tm1Amc/Wnt5a⁺ Wnt5b^tm1Tmj/Wnt5b^tm1Tmj
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4^tm1Amc mutation (2 available); any Wnt4 mutation (23 available)
Wnt5a^tm1Amc mutation (1 available); any Wnt5a mutation (41 available)
Wnt5b^tm1Tmj mutation (0 available); any Wnt5b mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal motor neuron morphology ( J:155074 )

• at E13.5, median motor column motor neurons at the thoracic level are decreased 63% compared to in wild-type mice

• mice exhibit a 50% reduction in median motor column motor neurons at the lumbar level compared with wild-type mice

• at the hind limb level, the total number of motor neurons is decreased 20% while the ratio of median motor column motor neurons is decreased 50% compared to in wild-type mice

• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased 50% compared to in wild-type mice

decreased motor neuron number ( J:155074 )

• at the hind limb level, the total number of motor neurons is decreased 20% compared to in wild-type mice

limbs/digits/tail

abnormal limb morphology ( J:155074 )

Allelic Composition	Wnt4^tm1Amc/Wnt4^tm1Amc Wnt5a^tm1Amc/Wnt5a⁺
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal motor neuron morphology ( J:155074 )

• at E13.5, median motor column motor neurons at the thoracic level are decreased 46% compared to in wild-type mice

• the ratio of median motor column motor neurons at the hind limb level is decreased compared to in wild-type mice

• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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