Phenotypes associated with this allele

• Allele Symbol: Prrx1^tm1Jfm
• Allele Name: targeted mutation 1, James F Martin
• Allele ID: MGI:1857531
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prrx1^tm1Jfm/Prrx1^tm1Jfm	involves: 129S4/SvJae	MGI:3775634
hm2	Prrx1^tm1Jfm/Prrx1^tm1Jfm	involves: 129S4/SvJaeSor	MGI:3687213
ht3	Prrx1^tm1Jfm/Prrx1^tm1Tex	involves: 129S4/SvJaeSor * 129S7/SvEvBrd	MGI:3687308
cx4	Prrx1^tm1Jfm/Prrx1^tm1Jfm Prrx2^tm1Mjk/Prrx2^tm1Mjk	involves: 129S4/SvJaeSor	MGI:3687311

Genotype
MGI:3775634

hm1

• Allelic Composition: Prrx1^tm1Jfm/Prrx1^tm1Jfm
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

short limbs ( J:131364 )

• forelimbs are 12.5% shorter than controls at E18.5; hindlimbs are significantly shortened

Genotype
MGI:3687213

hm2

• Allelic Composition: Prrx1^tm1Jfm/Prrx1^tm1Jfm
• Genetic Background: involves: 129S4/SvJaeSor

mortality/aging

neonatal lethality, complete penetrance ( J:99153 )

• die soon after birth from respiratory distress

growth/size/body

decreased body size ( J:99153 )

homeostasis/metabolism

cyanosis ( J:99153 )

respiratory system

abnormal lung vasculature morphology ( J:99153 )

• contain markedly reduced numbers of von Willebrand factor-positive blood vessels in lung tissue

pulmonary hypoplasia ( J:99153 )

• hypoplastic lung tissue

respiratory distress ( J:99153 )

cardiovascular system

abnormal lung vasculature morphology ( J:99153 )

• contain markedly reduced numbers of von Willebrand factor-positive blood vessels in lung tissue

Genotype
MGI:3687308

ht3

• Allelic Composition: Prrx1^tm1Jfm/Prrx1^tm1Tex
• Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

mortality/aging

neonatal lethality ( J:51596 )

• phenotype is stated to be a phenocopy of the single Prrx1^tm1Tex homozygotes, however no data is presented in J:51596

craniofacial

abnormal cranium morphology ( J:51596 )

skeleton

abnormal cranium morphology ( J:51596 )

abnormal long bone morphology ( J:51596 )

respiratory system

abnormal respiration ( J:51596 )

Genotype
MGI:3687311

cx4

• Allelic Composition: Prrx1^tm1Jfm/Prrx1^tm1Jfm; Prrx2^tm1Mjk/Prrx2^tm1Mjk
• Genetic Background: involves: 129S4/SvJaeSor

mortality/aging

neonatal lethality ( J:51596 )

• phenotypes are stated to be identical to double homozygous Prxx1^tm1Tex and Prrx2^tm1Mjk mutants, however data is not presented in J:51596

behavior/neurological

aphagia ( J:51596 )

craniofacial

abnormal Meckel's cartilage morphology ( J:51596 )

absent incisors ( J:51596 )

abnormal tooth development ( J:51596 )

abnormal ameloblast morphology ( J:51596 )

growth retardation of incisors ( J:51596 )

abnormal mandible morphology ( J:51596 )

short mandible ( J:51596 )

abnormal maxilla morphology ( J:51596 )

cleft palate ( J:51596 )

abnormal ear position ( J:51596 )

small ears ( J:51596 )

hearing/vestibular/ear

abnormal ear position ( J:51596 )

small ears ( J:51596 )

homeostasis/metabolism

cyanosis ( J:51596 )

limbs/digits/tail

abnormal limb morphology ( J:51596 )

respiratory system

respiratory distress ( J:51596 )

skeleton

abnormal Meckel's cartilage morphology ( J:51596 )

absent incisors ( J:51596 )

abnormal tooth development ( J:51596 )

abnormal ameloblast morphology ( J:51596 )

growth retardation of incisors ( J:51596 )

abnormal mandible morphology ( J:51596 )

short mandible ( J:51596 )

abnormal maxilla morphology ( J:51596 )

vision/eye

absent eyelids ( J:51596 )

eyelids open at birth ( J:51596 )

digestive/alimentary system

cleft palate ( J:51596 )

growth/size/body

absent incisors ( J:51596 )

abnormal tooth development ( J:51596 )

abnormal ameloblast morphology ( J:51596 )

growth retardation of incisors ( J:51596 )

abnormal mandible morphology ( J:51596 )

short mandible ( J:51596 )

abnormal maxilla morphology ( J:51596 )

cleft palate ( J:51596 )

abnormal ear position ( J:51596 )

small ears ( J:51596 )