Prrx1^tm1Jfm
Targeted Allele Detail

Summary

• Symbol: Prrx1^tm1Jfm
• Name: paired related homeobox 1; targeted mutation 1, James F Martin
• MGI ID: MGI:1857531
• Synonyms: Prx-1^lacZ
• Gene: Prrx1 Location: Chr1:163072688-163141279 bp, - strand Genetic Position: Chr1, 70.53 cM
• Alliance: Prrx1^tm1Jfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51596
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene was inserted in-frame at the 5' end of the homeobox domain. A PGK- neomycin cassette was introduced 3' of the lacZ in the reverse transcriptional orientation. (J:51596)

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prrx1 Mutation: 31 strains or lines available

References

• Original: J:51596 Lu MF, et al., prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme. Development. 1999 Feb;126(3):495-504
• All: 4 reference(s)