About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rxra+
wild type
MGI:1857512
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Rxratm2Ipc/Rxra+ involves: 129 MGI:2176969
ht2
 		Rxratm1Rev/Rxra+ involves: 129S4/SvJae * C57BL/6 MGI:2176444
cn3
 		Rxratm1Krc/Rxra+
Tg(Pbsn-cre)4Prb/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:2449982


Genotype
MGI:2176969
ht1
Allelic
Composition		 Rxratm2Ipc/Rxra+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxratm2Ipc mutation (0 available); any Rxra mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
abnormal postnatal growth/weight/body size ( J:20550 )




Genotype
MGI:2176444
ht2
Allelic
Composition		 Rxratm1Rev/Rxra+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxratm1Rev mutation (1 available); any Rxra mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
pulmonary artery stenosis ( J:35363 )
• one heterozygote shows pulmonary artery stenosis
abnormal myocardial trabeculae morphology ( J:35363 )
• 49% show trabecular defects with less organized trabecular arrangement
abnormal myocardium compact layer morphology ( J:35363 )
• intermediate thickness of compact layer compared to homozygotes and wild-type, especially prominent at E13.5 and 14.5
abnormal heart development ( J:35363 )
• 15% exhibit conotruncal defects, with severity ranging from absent conotruncal ridges (3%) to a shortened conotruncal septum (7%)
double outlet right ventricle ( J:35363 )
• seen in 5% of heterozygotes
abnormal atrioventricular valve morphology ( J:35363 )
• atrioventricular cushion defects range from absent fusion (3%) and hypoplasia (8%) to abnormalities of mature valvular structures
abnormal mitral valve morphology ( J:35363 )
• 17% show cleft mitral valve
mitral valve stenosis ( J:35363 )
• 2% show mitral valve stenosis
abnormal tricuspid valve morphology ( J:35363 )
• 8% show tricuspid valve abnormalities
abnormal ventricle papillary muscle morphology ( J:35363 )
• 86% show papillary muscle defects
thin ventricular wall ( J:35363 )
• severe thinning of the ventricular wall is seen in both the left (2%) and right (2%) ventricles, but never simultaneously
decreased heart left ventricle wall thickness ( J:35363 )
• thin left ventricle wall is associated with mitral valve stenosis yet a normal right ventricle and semilunar va
decreased heart right ventricle wall thickness ( J:35363 )
• thin right ventricle is associated with dysmorphic tricuspid valve yet normal left-sided and semilunar structures

muscle
abnormal myocardial trabeculae morphology ( J:35363 )
• 49% show trabecular defects with less organized trabecular arrangement
abnormal myocardium compact layer morphology ( J:35363 )
• intermediate thickness of compact layer compared to homozygotes and wild-type, especially prominent at E13.5 and 14.5
abnormal ventricle papillary muscle morphology ( J:35363 )
• 86% show papillary muscle defects

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
congenital heart disease DOID:1682 J:35363




Genotype
MGI:2449982
cn3
Allelic
Composition		 Rxratm1Krc/Rxra+
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxratm1Krc mutation (1 available); any Rxra mutation (28 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal prostate gland branching morphogenesis ( J:78553 )
• branching morphogenesis of the prostate ductal system is increased 54% and 52% in the lateral prostate and anterior prostate, respectively
prostate gland epithelial hyperplasia ( J:78553 )
• prostate hyperplasia after 11 months of age
increased prostate intraepithelial neoplasia incidence ( J:78553 )
• low grade prostatic intraepithelial neoplasia after 14 months of age
• after 18 months of age, some animals progress to high grade prostatic intraepithelial neoplasia

endocrine/exocrine glands
abnormal prostate gland branching morphogenesis ( J:78553 )
• branching morphogenesis of the prostate ductal system is increased 54% and 52% in the lateral prostate and anterior prostate, respectively
prostate gland epithelial hyperplasia ( J:78553 )
• prostate hyperplasia after 11 months of age
increased prostate intraepithelial neoplasia incidence ( J:78553 )
• low grade prostatic intraepithelial neoplasia after 14 months of age
• after 18 months of age, some animals progress to high grade prostatic intraepithelial neoplasia

neoplasm
increased prostate intraepithelial neoplasia incidence ( J:78553 )
• low grade prostatic intraepithelial neoplasia after 14 months of age
• after 18 months of age, some animals progress to high grade prostatic intraepithelial neoplasia




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory