Phenotypes associated with this allele

• Allele Symbol: Ascl1⁺
• Allele Name: wild type
• Allele ID: MGI:1857485
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ascl1^tm1And/Ascl1^+	involves: 129	MGI:4941570
ht2	Ascl1^tm1(Neurog2)Fgu/Ascl1^+	involves: 129S1/Sv * 129X1/SvJ	MGI:4420911
ht3	Ascl1^tm1.1(cre/ERT2)Jejo/Ascl1^+	involves: 129S6/SvEvTac	MGI:5298095

Genotype
MGI:4941570

ht1

• Allelic Composition: Ascl1^tm1And/Ascl1⁺
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased solitary pulmonary neuroendocrine cell number ( J:64088 )

• the number of CGRP-positive pulmonary neuroendocrine cells (including single and clustered PNECs) is significantly reduced in E13-E17 and neonatal heterozygous mutant lungs relative to that in wild-type lungs

respiratory system

decreased number of pulmonary neuroendocrine bodies ( J:64088 )

• the number of clustered PNECs is significantly reduced in E13-E17 and neonatal heterozygous mutant lungs relative to that in wild-type lungs

endocrine/exocrine glands

decreased solitary pulmonary neuroendocrine cell number ( J:64088 )

• the number of CGRP-positive pulmonary neuroendocrine cells (including single and clustered PNECs) is significantly reduced in E13-E17 and neonatal heterozygous mutant lungs relative to that in wild-type lungs

Genotype
MGI:4420911

ht2

• Allelic Composition: Ascl1^{tm1(Neurog2)Fgu}/Ascl1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

nervous system

abnormal dorsal interneuron 2 morphology ( J:98830 )

• in E11.5 embryos, increase in dI2 numbers

abnormal dorsal interneuron 3 morphology ( J:98830 )

• in E11.5 embryos, increase in dI3 numbers

Genotype
MGI:5298095

ht3

• Allelic Composition: Ascl1^{tm1.1(cre/ERT2)Jejo}/Ascl1⁺
• Genetic Background: involves: 129S6/SvEvTac

normal phenotype

no abnormal phenotype detected ( J:171439 )