Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1tm1Gru mutation
(7 available);
any
Cd1 mutation
(7 available)
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cardiovascular system
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• area of choroidal neovascularization induced by photocoagulation is significantly reduced
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vision/eye
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• area of choroidal neovascularization induced by photocoagulation is significantly reduced
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1tm1Gru mutation
(7 available);
any
Cd1 mutation
(7 available)
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mortality/aging
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• cumulative mortality 7 days after infection with Coxsackie virus is 25% as compared to 67% for controls
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immune system
N |
• despite near absence of IL-4-secreting NK-like T cells in the thymus, homozygotes are able to mount a normal TH2 response producing IgE levels comparable to those detected in control littermates after immunization with anti-IgD
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• reduced incidence of myocarditis caused by Coxsackie virus infection
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• substantial reduction in airway eosinophilia in response to OVA challenge
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• decreased Interferon gamma positive CD4+ cells
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• homozygotes show near absence of the NK-like thymocyte population that secretes large amounts of IL-4 immediately after T cell receptor ligation and is characterized as heat-stable antigen (HAS)-/low, Vbeta8int CD44high (the
NK1.1 marker is not expressed in the 129 and BALB/c genetic background of homozygous mutant mice)
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• in vivo, homozygotes fail to promptly produce IL-4 after intravenous injection with anti-CD3
• in contrast, the induction of IFN-gamma mRNA after T cell receptor ligation remains unaffected
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• cumulative mortality 7 days after infection with Coxsackie virus is 25% as compared to 67% for controls
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hematopoietic system
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• substantial reduction in airway eosinophilia in response to OVA challenge
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• decreased Interferon gamma positive CD4+ cells
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• homozygotes show near absence of the NK-like thymocyte population that secretes large amounts of IL-4 immediately after T cell receptor ligation and is characterized as heat-stable antigen (HAS)-/low, Vbeta8int CD44high (the
NK1.1 marker is not expressed in the 129 and BALB/c genetic background of homozygous mutant mice)
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neoplasm
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• metastasis to the lung is reduced as measured by iv injection of colon carcinoma cell line CT26
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cardiovascular system
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• reduced incidence of myocarditis caused by Coxsackie virus infection
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respiratory system
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• hyper-reactivity does not develop in response to OVA challenge
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