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Targeted Allele Detail
Symbol: Cd1tm1Gru
Name: CD1 antigen complex; targeted mutation 1, Michael Grusby
MGI ID: MGI:1857482
Synonyms: CD1-, Cd1d-, Cd1d1/Cd1d2tm1Gru, CD1d KO, CD1tm1Gru
Gene: Cd1  Location: unknown  Genetic Position: Chr3, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:47769
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
  Cd1tm1Gru involves 2 genes/genome features (Cd1d2, Cd1d1) View all
Mutation detailsBoth the Cd1d1 gene and the adjacent Cd1d2 gene were mutated in this allele. The coding sequence of Cd1d1 was replaced with a neomycin selection cassette and the coding sequence of Cd1d2 was deleted; however, the intergenic sequence was retained. Flow cytometric analysis on thymocytes derived from homozygous mice confirmed that no stable encoded protein was expressed on the cell surface. (J:47769)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Cd1tm1Gru
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Cd1 Mutation:  7 strains or lines available
Original:  J:47769 Smiley ST, et al., Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science. 1997 Feb 14;275(5302):977-9
All:  117 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory