Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grprtm1Jfb mutation
(1 available);
any
Grpr mutation
(14 available)
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normal phenotype
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• female homozygotes are viable, fertile and developmentally normal with no pathological or histological abnormalities in all major organ systems up to 10 months of age
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behavior/neurological
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N |
• spontaneous scratching, seen in mutant mice wild-type for Grpr, is markedly diminished
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behavior/neurological
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• compound mutant mice show elevated scratching compared to wild-type but this is significantly reduced from that shown by mutants with intact Grpr function
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grprtm1Jfb mutation
(1 available);
any
Grpr mutation
(14 available)
Nmbrtm1Hoh mutation
(0 available);
any
Nmbr mutation
(22 available)
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behavior/neurological
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N |
• mice exhibit normal responses to a wide array of noxious stimuli
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Allelic
Composition |
Grprtm1Jfb/Y
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Genetic
Background |
involves: 129X1/SvJ * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grprtm1Jfb mutation
(1 available);
any
Grpr mutation
(14 available)
|
|
|
behavior/neurological
 |
• male hemizygotes are viable, fertile and developmentally normal with no pathological or histological abnormalities in all major organ systems up to 10 months of age
• however, male hemizygotes lack a bombesin (BN)-induced satiety response: BN produces a significant suppression of glucose intake in wild-type mice at doses of 3.2, 10, and 32 nmol/kg but fails to suppress glucose intake at any dose with no apparent weight gain in mutant males
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Analysis Tools
