Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm5tm1Rod mutation
(2 available);
any
Grm5 mutation
(75 available)
|
|
|
behavior/neurological
 |
• mice exhibit impaired pairwise visual discrimination, requiring more trials to reach criterion, performing more correction trials, and increased preservation index
|
|
|
• mice are impaired on early reversal learning, taking more trials to reach criterion and requiring more correction trials overall and when adjusting for other factors and exhibit this similar phenotype on late reversal learning
• mice are impaired at extinction, responding at a higher rate throughout the extinction sessions
• mice show no differences in locomotor activity, reward collection time or latency to touch stimuli across reversal learning
|
|
|
• mice exhibit impaired pairwise visual discrimination, requiring more trials to reach criterion, performing more correction trials, and increased preservation index
• mice show no differences in locomotor activity, reward collection time or latency to touch stimuli across visual discrimination
|
|
|
• mice are impaired on early reversal learning, taking more trials to reach criterion and requiring more correction trials overall and when adjusting for other factors and exhibit this similar phenotype on late reversal learning
• mice are impaired at extinction, responding at a higher rate throughout the extinction sessions
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm5tm1Rod mutation
(2 available);
any
Grm5 mutation
(75 available)
|
|
|
behavior/neurological
|
|
• mutants do not show any locomotor stimulation in response to a Grm5, MPEP, antagonist whereas wild-type littermates display increased locomotor activity
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm5tm1Rod mutation
(2 available);
any
Grm5 mutation
(75 available)
|
|
|
nervous system
|
|
• field excitatory postsynaptic potential (fEPSP) depression by (1S,3R)-1-amino-cyclopentane-1,3-dicarboxylic acid (ACPD) is attenuated (12+/-10% compared to 55.5+/-4.6% in wild-type mice at 50uM ACPD)
• however, fEPSP depression by ACPD at 300uM is normal
|
|
|
• significant reduction in long term depression (LTP) in NMDA receptor-dependent pathways, such as the CA1 region and dentate gyrus of the hippocampus, but not in NMDA receptor-independent pathways, such as the mossy fiber synapses of the CA3 region
• LTP in the last 30 minutes after tetanus was 50.2+/-5.7% above baseline compared to 77.6+/-10.2% above base line in wild-type mice
|
behavior/neurological
|
|
• mice exhibit a decrease in contextual fear conditioning
|
|
|
• mice exhibit decreased learning acquisition in a hidden platform water maze
• in a water maze, mice spend less time searching for the target quadrant and cross the platform less frequently when compared with wild-type mice
• however, locomotion and performance in an open field test are normal
|
Allelic
Composition |
Grm5tm1Rod/Grm5+
|
|
Genetic
Background |
involves: 129 * C57BL/6 * FVB |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm5tm1Rod mutation
(2 available);
any
Grm5 mutation
(75 available)
|
|
|
nervous system
|
|
• deprived-eye depression is reduced following monocular depression in comparison to controls
|
Allelic
Composition |
Fmr1tm1Cgr/Y
Grm5tm1Rod/Grm5+
|
|
Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 * FVB |
|
|
|
behavior/neurological
|
N |
• latency to enter box following the inhibitory avoidance test is similar to wildtype, but significantly different from mice of the genotype Fmr1tm1Cgr/Y
|
|
|
• 33.3% of mice have a seizure in response to the test tone
|
nervous system
|
N |
• visually evoked potentials are similar to wildtype control
• dendritic spine density is similar to wildtype control, but less than Fmr1tm1Cgr/Y mice
|
|
|
• 33.3% of mice have a seizure in response to the test tone
|
growth/size/body
|
N |
• adult body weight is similar to wild-type, but less than Fmr1tm1Cgr/Y mice
|
endocrine/exocrine glands
|
|
• increase is only observed in adult (11-12 weeks)
|
reproductive system
|
|
• increase is only observed in adult (11-12 weeks)
|
Analysis Tools