Phenotypes associated with this allele

• Allele Symbol: Mycn⁺
• Allele Name: wild type
• Allele ID: MGI:1857406
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mycn^tm2.1Nagy/Mycn^+	involves: 129S1/Sv * 129X1/SvJ	MGI:2385451
ht2	Mycn^tm2Nagy/Mycn^+	involves: 129S1/Sv * 129X1/SvJ	MGI:2385450
ht3	Mycn^tm1Par/Mycn^+	involves: 129S2/SvPas * C57BL/6J	MGI:3620014
cn4	Mycn^tm1Psk/Mycn^+ Tg(Sftpc-cre)1Blh/0	involves: 129 * C57BL/6 * ICR	MGI:3575016

Genotype
MGI:2385451

ht1

• Allelic Composition: Mycn^tm2.1Nagy/Mycn⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

kinked tail ( J:67930 )

• due to vertebral fusions; authors report 25% penetrance in "outbred" background and 100% penetrance in "inbred 129" background

skeleton

vertebral fusion ( J:67930 )

Genotype
MGI:2385450

ht2

• Allelic Composition: Mycn^tm2Nagy/Mycn⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

limbs/digits/tail

kinked tail ( J:67930 )

• kinks in the proximal part of the tail because of vertebral fusion

• authors report 25% penetrance in "outbred" background and 100% penetrance in "inbred 129" background

Genotype
MGI:3620014

ht3

• Allelic Composition: Mycn^tm1Par/Mycn⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

mortality/aging

postnatal lethality, incomplete penetrance ( J:3432 )

• heterozygotes are present at the expected Mendelian ratio at E18.5 but are significantly under-represented at 3 weeks

• surviving heterozygotes are fertile, healthy and exhibit no differences in size, weight, or lifespan relative to wild-type mice

Genotype
MGI:3575016

cn4

• Allelic Composition: Mycn^tm1Psk/Mycn⁺; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129 * C57BL/6 * ICR

mortality/aging

decreased survivor rate ( J:97215 )

• ~50% of mutants develop normally into adulthood with no obvious lung defects

neonatal lethality, incomplete penetrance ( J:97215 )

• ~50% of mutants die at or shortly after birth with a severe lung phenotype

respiratory system

abnormal lung morphology ( J:97215 )

• at E18.5 the lungs of affected mutants are composed of numerous large fluid-filled sacs containing cellular debris lined by highly attenuated epithelial cells separated by a thin layer of mesoderm

• however, lung size, lobulation pattern, and trachea morphology are normal

abnormal lung development ( J:97215 )

• at E15.5-E16.5, a reduction in the proportion of proliferating cells in the endoderm is seen

• at E15.5, E16.5 and E18.5, abundant apoptotic cells are detected in the lumen, epithelium and mesenchyme, unlike in wild-type lungs

abnormal branching involved in lung morphogenesis ( J:97215 )

• at E14.5-E16.5 in affected mutants, branching is reduced with only a few expanded tubes separated by abundant mesoderm present

abnormal lung epithelium morphology ( J:97215 )

• at E14.5, E15.5 and E18.5, epithelial cell size is irregular, dead cells are seen in the lumen, and increased apoptosis is seen

decreased type I pneumocyte number ( J:97215 )

• at E18.5, attenuated presumptive type I cells are lining the large sacs

decreased type II pneumocyte number ( J:97215 )

• at E18.5, a paucity of type II cells is observed in the mutant lung