Mycn^tm2Nagy
Targeted Allele Detail

Summary

• Symbol: Mycn^tm2Nagy
• Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; targeted mutation 2, Andras Nagy
• MGI ID: MGI:2178229
• Synonyms: N-myc^Pneo
• Gene: Mycn Location: Chr12:12986094-12991837 bp, - strand Genetic Position: Chr12, 6.14 cM, cytoband A3-B
• Alliance: Mycn^tm2Nagy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67930
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Point mutations were introduced that altered both codon 432 from one encoding leucine to proline, and one neutral point mutation at codon 430 that created a PvuII site. A loxP-flanked neomycin selection cassette was also inserted into an adjacent intron. (J:67930)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mycn Mutation: 24 strains or lines available

References

• Original: J:67930 Nagy A, et al., Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles. Curr Biol. 1998 May 21;8(11):661-4
• All: 1 reference(s)