All Phenotypes Mstn<Cmpt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mstn^Cmpt
compact
MGI:1857404

Summary

2 genotypes

Allelic Composition	Mstn^Cmpt/Mstn^Cmpt
Genetic Background	BEH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mstn^Cmpt mutation (0 available); any Mstn mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

increased skeletal muscle mass ( J:119757 )

• 2 month old females show significantly lower specific force measurements compared with wild-type controls

Allelic Composition	Mstn^Cmpt/Mstn⁺
Genetic Background	either: HCI or HCR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mstn^Cmpt mutation (0 available); any Mstn mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle morphology ( J:43299 )

increased skeletal muscle mass ( J:43299 )

• hypermuscularity is variable but always greater than found in wild-type mice

• phenotype is more distinct among males

• variable expression depends on presence/absence of at least one modifier

growth/size/body

abnormal body composition ( J:43299 )

increased body weight ( J:43299 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
myostatin-related muscle hypertrophy		DOID:0111072	OMIM:614160	J:43299

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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