All Phenotypes Ptprc<tm1Holm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprc^tm1Holm/Ptprc^tm1Holm	involves: 129/Sv * C57BL/6	MGI:3032848
cx2	Ptprc^tm1Holm/Ptprc^tm1Holm Tg(Lck*F505)2964Rmp/?	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3032909
cx3	Ptprc^tm1Holm/Ptprc^tm1Holm Tg(Lck*F505)3073Rmp/?	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3032910

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

spleen hyperplasia ( J:33466 )

• numbers of lymphoid cells in the spleen are greatly increased

abnormal lymphopoiesis ( J:33466 )

abnormal T cell differentiation ( J:33466 )

• double positive to single positive transition inhibition is first noticeable in the first day after birth

increased double-negative T cell number ( J:33466 )

• proportion of double negative cells considerably increased

decreased double-positive T cell number ( J:33466 )

• double positive cells express elevated amounts of CD4 and CD8

• 2 fold decrease in double positive T cells

• double negative to double positive transition inhibition is first noticeable at E18

abnormal B cell number ( J:33466 )

• percentage of B cells in the spleen is normal

• absolute number of B cells in the spleen is 2X normal

• percentage of splenic B cells expressing high levels of IgM is increased although absolute numbers of low IgM cells is normal

decreased T cell number ( J:33466 )

• adult phenotype is established in the first week after birth

• 20% reduction in numbers of mature T cells in the spleen

decreased thymocyte number ( J:33466 )

• 50% reduction in total numbers of thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:33466 )

• CD4+ cells reduced to about 10% of normal

decreased CD8-positive, alpha-beta T cell number ( J:33466 )

• cell numbers are greatly reduced

immune system

spleen hyperplasia ( J:33466 )

• numbers of lymphoid cells in the spleen are greatly increased

abnormal lymphopoiesis ( J:33466 )

abnormal T cell differentiation ( J:33466 )

• double positive to single positive transition inhibition is first noticeable in the first day after birth

increased double-negative T cell number ( J:33466 )

• proportion of double negative cells considerably increased

decreased double-positive T cell number ( J:33466 )

• double positive cells express elevated amounts of CD4 and CD8

• 2 fold decrease in double positive T cells

• double negative to double positive transition inhibition is first noticeable at E18

abnormal B cell number ( J:33466 )

• percentage of B cells in the spleen is normal

• absolute number of B cells in the spleen is 2X normal

• percentage of splenic B cells expressing high levels of IgM is increased although absolute numbers of low IgM cells is normal

decreased T cell number ( J:33466 )

• adult phenotype is established in the first week after birth

• 20% reduction in numbers of mature T cells in the spleen

decreased thymocyte number ( J:33466 )

• 50% reduction in total numbers of thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:33466 )

• CD4+ cells reduced to about 10% of normal

decreased CD8-positive, alpha-beta T cell number ( J:33466 )

• cell numbers are greatly reduced

endocrine/exocrine glands

decreased thymocyte number ( J:33466 )

• 50% reduction in total numbers of thymocytes

growth/size/body

spleen hyperplasia ( J:33466 )

• numbers of lymphoid cells in the spleen are greatly increased

Allelic Composition	Ptprc^tm1Holm/Ptprc^tm1Holm Tg(Lck*F505)2964Rmp/?
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprc^tm1Holm mutation (11 available); any Ptprc mutation (188 available)
Tg(Lck*F505)2964Rmp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:64671 )

• aggressive thymic tumors in 100% of mice

• extensive metastasis

• earliest morbidity at 5 weeks and median survival was to 9.5 weeks

• thymomas originate from immature thymocytes

immune system

thymus hyperplasia ( J:64671 )

• thymus glands with tumours also have 5X normal cell numbers

hematopoietic system

thymus hyperplasia ( J:64671 )

• thymus glands with tumours also have 5X normal cell numbers

endocrine/exocrine glands

thymus hyperplasia ( J:64671 )

• thymus glands with tumours also have 5X normal cell numbers

increased T cell derived lymphoma incidence ( J:64671 )

• aggressive thymic tumors in 100% of mice

• extensive metastasis

• earliest morbidity at 5 weeks and median survival was to 9.5 weeks

• thymomas originate from immature thymocytes

Allelic Composition	Ptprc^tm1Holm/Ptprc^tm1Holm Tg(Lck*F505)3073Rmp/?
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprc^tm1Holm mutation (11 available); any Ptprc mutation (188 available)
Tg(Lck*F505)3073Rmp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:64671 )

• aggressive thymic tumors in 100% of mice

• earliest morbidity at 10 weeks and median survival was to 12 weeks

immune system

thymus hyperplasia ( J:64671 )

• thymus glands with tumours also have 5X normal cell numbers

hematopoietic system

thymus hyperplasia ( J:64671 )

• thymus glands with tumours also have 5X normal cell numbers

endocrine/exocrine glands

thymus hyperplasia ( J:64671 )

• thymus glands with tumours also have 5X normal cell numbers

increased T cell derived lymphoma incidence ( J:64671 )

• aggressive thymic tumors in 100% of mice

• earliest morbidity at 10 weeks and median survival was to 12 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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